ZK118182 isopropyl ester Chemical Properties

Boiling point:

553.1±50.0 °C(Predicted)

Density 

1.14±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml

pka

14.22±0.70(Predicted)

ZK118182 isopropyl ester Usage And Synthesis

Description

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF_2α and PGD₂, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC₅₀ = 16.5 nM) and a high nanomolar affinity for the DP receptor (K_i = 74 nM). ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 μg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.

Uses

ZK118182 Isopropyl ester is the isopropyl ester analog of ZK118182, a prostaglandin analog[1].

References

[1] Sharif N A, et al. Molecular pharmacology of the DP/EP2 class prostaglandin AL-6598 and quantitative autoradiographic visualization of DP and EP2 receptor sites in human eyes[J]. Journal of Ocular Pharmacology & Therapeutics, 2004, 20(6): 489-508.

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