Basic information Safety Supplier Related

LEU-LEU METHYL ESTER HYDROBROMIDE

Basic information Safety Supplier Related

LEU-LEU METHYL ESTER HYDROBROMIDE Basic information

Product Name:
LEU-LEU METHYL ESTER HYDROBROMIDE
Synonyms:
  • H-LEU-LEU-OME HBR
  • LEU-LEU METHYL ESTER HYDROBROMIDE
  • H-Leu-Leu-OMe
  • LLME · HBr
  • Leu-Leu-Ome, HBr
  • (S)-Methyl 2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoate hydrobromide
  • Leu-Leu methyl ester hydrobromide >=97% (TLC)
  • L-Leucyl-L-Leucine methyl ester hydrobromide
CAS:
16689-14-8
MF:
C13H27BrN2O3
MW:
339.27
Product Categories:
  • Dipeptides
  • Dipeptides and Tripeptides
  • Peptides
Mol File:
16689-14-8.mol
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LEU-LEU METHYL ESTER HYDROBROMIDE Chemical Properties

storage temp. 
−20°C
solubility 
Soluble in DMSO (up to 35 mg/ml) or in Water (up to 40 mg/ml)
form 
solid
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
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Safety Information

WGK Germany 
3

MSDS

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LEU-LEU METHYL ESTER HYDROBROMIDE Usage And Synthesis

Description

Leu-Leu-OMe (16689-14-8) is a lysosomal damaging agent (lysosomotropic). It is condensed into a membranolytic polymer via the transpeptidase action of cathepsin C within lysosomes.1,2 May be used to induce a lysosomal damage model in cells.3,4? LLOMe-induced lysosomal damage elicits ubiquitin puncta formation on lysosomes.1 Induces apoptosis in human mast cells via lysosome destabilization leaving fibroblasts and HEK-293 cells largely resistant.5 Induces lysophagy.4

Uses

H-Leu-Leu-OMe·HBr is a useful research chemical compound used in the preparation of octapeptide derivatives and intermediates.

References

1) Maejima et al. (2013), Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury; EMBO J., 32 2336 2) Fujita et al. (2013), Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin; J. Cell Biol., 203 115 3) Chauhan et al. (2016), TRIMS and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-directed Autophagy in Endomembrane Damage Homeostasis; Dev. Cell, 39 13 4) Otomo and Yoshimori (2017), Lysophagy: A Method for Monitoring Lysosomal Rupture Followed by Autophagy-Dependent Recovery; Methods Mol. Biol. 1594 141 5) Melo et al. (2011), Lysosomal membrane permeabilization induces cell death in human mast cells; Scand. J. Immunol., 74 354

LEU-LEU METHYL ESTER HYDROBROMIDESupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
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