Furowanin A
Furowanin A Basic information
- Product Name:
- Furowanin A
- Synonyms:
-
- 6-(3,4-Dihydroxyphenyl)-2,3-dihydro-4-hydroxy-2-(1-hydroxy-1-methylethyl)-9-(3-methyl-2-buten-1-yl)-5H-furo[3,2-g][1]benzopyran-5-one
- Furowanin A
- 5H-Furo[3,2-g][1]benzopyran-5-one, 6-(3,4-dihydroxyphenyl)-2,3-dihydro-4-hydroxy-2-(1-hydroxy-1-methylethyl)-9-(3-methyl-2-buten-1-yl)-
- CAS:
- 911004-72-3
- MF:
- C25H26O7
- MW:
- 438.47
- Mol File:
- 911004-72-3.mol
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Furowanin A Chemical Properties
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
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Furowanin A Usage And Synthesis
Description
Furowanin A shows significant cytotoxicity against HL-60 cells. Furowanin A induces that Caspase-9 and caspase-3 inhibitors suppresses apoptosis.
Uses
Furowanin A is a flavonoid with anti-neoplastic effects. Furowanin A inhibits STAT3/Mcl-1 axis to suppress proliferation, block cell cycle progression, induce apoptosis and promote autophagy. Furowanin A potently inhibits colorectal cancer (CRC) cells[1].
target
Caspase
IC 50
Mcl-1; STAT3
References
[1] Ma Z, et al. Furowanin A-induced autophagy alleviates apoptosis and promotes cell cycle arrest via inactivation STAT3/Mcl-1 axis in colorectal cancer. Life Sci. 2019 Feb 1;218:47-57. DOI:10.1016/j.lfs.2018.12.027
Furowanin ASupplier
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