S-Cyclopropylglycine Methyl ester hydrochloride Chemical Properties

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to off-white Solid

optical activity

98.128°(C=0.46 g/100mI, MEOH , 20°C, 589nm)

Safety Information

HS Code 

2922498590

S-Cyclopropylglycine Methyl ester hydrochloride Usage And Synthesis

Synthesis

(S)-2-Amino-2-cyclopropylacetic acid (10.0 g, 86.9 mmol) was slowly added to a solution of anhydrous methanol (750 mL) containing thionyl chloride (7.6 mL, 104 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and subsequently heated to reflux for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to give the crude product. The crude product was washed with acetone to yield 8.94 g of L-cyclopropylglycine methyl ester hydrochloride as a white solid. The yield was 62% and the mass spectrum (MS) showed a molecular ion peak of 130 (M+H+) and a melting point of 134.0-135.9 °C.

References

[1] Patent: US2004/77646, 2004, A1. Location in patent: Page 88
[2] Patent: US2004/248949, 2004, A1. Location in patent: Page 33
[3] Journal of the American Chemical Society, 2015, vol. 137, # 5, p. 2042 - 2046
[4] Patent: US2018/110824, 2018, A1. Location in patent: Paragraph 0642; 0643; 0644

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