(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide
(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Basic information
- Product Name:
- (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide
- Synonyms:
-
- (E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide
- MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem
- (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide
- Necrosulfonami
- N-[4-[[(3-Methoxypyrazinyl)aMino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenaMide
- Necrosulfonamide(b)
- 2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-
- (E/Z)-Necrosulfonamide
- CAS:
- 432531-71-0
- MF:
- C18H15N5O6S2
- MW:
- 461.47
- Mol File:
- 432531-71-0.mol
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(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Chemical Properties
- storage temp.
- +2C to +8C
- solubility
- DMSO:100.0(Max Conc. mg/mL);216.7(Max Conc. mM)
- form
- Dark yellow solid
- color
- Light yellow to yellow
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(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Usage And Synthesis
Chemical Properties
Yellow Solid
Uses
Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.
Definition
ChEBI: Necrosulfonamide is a sulfonamide that is a 3-methoxypyrazin-2-yl derivative of (E)-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide. Necrosulfonamide specifically blocks necrosis downstream of the activation of RIP3 (the receptor-interacting serine-threonine kinase 3), a key signalling molecule in the programmed necrosis (necroptosis) pathway. It is a sulfonamide, a member of pyrazines and a member of thiophenes.
(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMideSupplier
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