9H-Purine-2-carbonitrile, 6-[(3,5-difluorophenyl)aMino]-9-ethyl- Chemical Properties

Boiling point:

504.1±60.0 °C(Predicted)

Density 

1.47±0.1 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

solubility 

DMSO : 80 mg/mL (266.43 mM);Water : < 0.1 mg/mL (insoluble)

pka

-1.62±0.10(Predicted)

form 

Solid

color 

White to off-white

9H-Purine-2-carbonitrile, 6-[(3,5-difluorophenyl)aMino]-9-ethyl- Usage And Synthesis

Uses

Cruzain-IN-1 is a covalent and reversible Cruzain inhibitor, with an IC50 of 10 nM.

Definition

ChEBI: 6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile is a member of 6-aminopurines.

IC 50

Trypanosoma: 10 nM (IC₅₀)

References

[1] Lee GM, et al. Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry. 2012 Dec 18;51(50):10087-98. DOI:10.1021/bi301305k

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