LUF 6000 Chemical Properties

Melting point:

237-240℃ (methanol water )

Boiling point:

650.5±55.0 °C(Predicted)

Density 

1.401±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 14.29 mg/mL (34.74 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)

form 

Powder

pka

12.13±0.40(Predicted)

color 

Light brown to brown

LUF 6000 Usage And Synthesis

Uses

LUF6000 is an orally active allosteric modulator of the A3 adenosine receptor. LUF6000 has potent anti-inflammatory effect[1][2].

in vivo

References

[1] Du L, et al. Species differences and mechanism of action of A3 adenosine receptor allosteric modulators. Purinergic Signal. 2018;14(1):59-71. DOI:10.1007/s11302-017-9592-1
[2] Cohen S, et al. A? adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action. Mediators Inflamm. 2014;2014:708746. DOI:10.1155/2014/708746