SR 1078
SR 1078 Basic information
- Product Name:
- SR 1078
- Synonyms:
-
- N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide
- SR 1078
- SR1078,N-[4-(2,2,2-Trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenyl]-4-trifluoroMethyl-benzaMide
- N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide SR1078
- SR1078;SR 1078;SR-1078
- N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]-4-(trifluoromethyl)benzamide
- SR1078,N-[4-(2,2,2-TRIFLUORO-1-HYDROXY-1-TRIFLUOROMETHYL-ETHYL)-PHENYL]-4-TRIFLU
- SR 1078; SR-1078
- CAS:
- 1246525-60-9
- MF:
- C17H10F9NO2
- MW:
- 431.25
- Mol File:
- 1246525-60-9.mol
SR 1078 Chemical Properties
- Melting point:
- 169℃
- Boiling point:
- 362.9±42.0 °C(Predicted)
- Density
- 1.527±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO, Methanol (Slightly)
- form
- Solid
- pka
- 9.21±0.15(Predicted)
- color
- Off-White
SR 1078 Usage And Synthesis
Uses
SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays.
Biological Activity
sr1078 is an agonist of retinoic acid receptor-related orphan receptor (ror) rorα and rorγ with ic50 values of both 1-3 μm [1].rorα and rorγ are two members of nuclear receptor superfamily, which possesses a highly conserved dna-binding and a ligand-binding domain. these two receptors are considered to play important roles in the regulation of metabolism and the function of immune system [1].sr1078 is a selective rorα and rorγ agonist, which activate rorα and rorγ directed transcription via inducing conformational changes [1].sr1078 selectively targets on rorα and rorγ as an agonist but not on lxr and fxr [1]. it was shown that sr1078 was able to stimulate ror activity and subsequent ror-directed mrna expression. when hepg2 cells were treated with sr1078 for 24h, the ror directed reporter gene fg21 mrna level was increased by 3-fold, while another reporter gene g6pase was increased by 2-fold [1].in mouse model, i.p. injection of 10 mg/kg sr1078 for 1 hr resulted in 3.6 μm plasma concentration., and after 8 hr the concentration still sustained at 800 nm. i.p. injection of 10 mg/kg sr1078 for 2 hr resulted in significantly increased level of mrna of reporter gene g6pase and fg21 [1].
storage
Store at +4°C
References
[1] wang y et al. , identification of a synthetic agonist for the orphan nuclear receptors rorα and rorγ, sr1078. acs chem biol., 2010, 5(11): 1029-1034.
SR 1078Supplier
- Tel
- sales@boylechem.com
- Tel
- 021-50718719 13918719472
- Tel
- 021-58950125
- info@chemexpress.com
- Tel
- 400-400-6206333 18521732826
- market@aladdin-e.com
- Tel
- 021-61552785
- sales@shshiji.com
SR 1078(1246525-60-9)Related Product Information
- SR-717
- SRT3025
- SR9009
- SR8278
- SR19881
- SR-9243
- SRPK inhibitor
- N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
- SRI 31215
- SR 0987
- SR27897
- SR17018
- N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine
- 2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamide
- 4-Quinolinecarboxamide, N-[3-[[[2-[4-(aminosulfonyl)phenyl]ethyl]amino]carbonyl]phenyl]-1,2-dihydro-2-oxo-
- SR-18292
- SR-4835
- SR18662