NG-25 Chemical Properties

Density 

1.313±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Soluble in DMSO

form 

powder

pka

12.91±0.70(Predicted)

color 

white to beige

Water Solubility 

H2O: 5mg/mL, clear

InChIKey

SMPGEBOIKULBCT-UHFFFAOYSA-N

SMILES

C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)(=O)C1=CC=C(C)C(OC2C=CN=C3NC=CC3=2)=C1

Safety Information

RIDADR 

UN 2811 6.1 / PGIII

NG-25 Usage And Synthesis

Uses

NG 25 inhibits TGF-beta-activated kinase 1 (TAK1). It also inhibits LYN, mitogen-activated protein kinase (MAP4K2) and Abl kinase activity.

Biochem/physiol Actions

NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.

IC 50

MAP4K2: 21.7 nM (IC₅₀); TAK1: 149 nM (IC₅₀); LYN: 12.9 nM (IC₅₀); GSK: 56.4 nM (IC₅₀); ABL,ARG: 75.2 nM (IC₅₀); FER: 82.3 nM (IC₅₀); SRC: 113 nM (IC₅₀); Eph B2: 672 nM (IC₅₀); ZAK: 698 nM (IC₅₀); Eph A2: 773 nM (IC₅₀); Eph B4: 999 nM (IC₅₀); ZC1/HGK: 3250 nM (IC₅₀); RAF1: 7590 nM (IC₅₀)

storage

Store at -20°C

NG-25(1315355-93-1)Related Product Information

• Hydroxyethyl piperazine
• N-Ethylacetamide
• 2-Aminoethyl(ethyl)amine
• N-Ethyl-3-methylaniline
• N-ethyl-pyrrolidone
• N-(2-Hydroxyethyl)-2-pyrrolidone