NG-25
NG-25 Basic information
- Product Name:
- NG-25
- Synonyms:
-
- 3-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide
- HG-7-92-01 (NG 25)
- N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
- 3-((1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3v-(trifluoromethyl)phenyl)-4-methylbenzamide
- N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
- NG25
- NG-25
- NG 25; NG-25
- CAS:
- 1315355-93-1
- MF:
- C29H30F3N5O2
- MW:
- 537.58
- Product Categories:
-
- Smad
- TGF-beta
- TGF-beta/Smad
- Mol File:
- 1315355-93-1.mol
More
Less
NG-25 Chemical Properties
- Density
- 1.313±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO
- form
- powder
- pka
- 12.91±0.70(Predicted)
- color
- white to beige
More
Less
NG-25 Usage And Synthesis
Uses
NG 25 inhibits TGF-beta-activated kinase 1 (TAK1). It also inhibits LYN, mitogen-activated protein kinase (MAP4K2) and Abl kinase activity.
Biochem/physiol Actions
NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.
storage
Store at -20°C
NG-25Supplier
Shanghai SuperLan Chemcial Technique Centre Gold
- Tel
- 021-2022843681 15618226720
- lucy@atkchemical.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
Shanghai Aladdin Bio-Chem Technology Co.,LTD
- Tel
- 400-400-6206333 18521732826
- market@aladdin-e.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
LETOPHARM LIMITED
- Tel
- +86-21-5821 5861
- sales@letopharm.com