ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Epigenetics > Epigenetic Reader Domain inhibitors > PFI-1
PFI-1
PFI-1 Basic information
- Product Name:
- PFI-1
- Synonyms:
-
- PFI-1
- PFI-1 (PF-6405761)
- PFI-1 (PF-06405761)
- PFI 1;PFI1
- CS-709
- PF-06405761
- Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)-
- 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide PFI-1 (PF-6405761)
- CAS:
- 1403764-72-6
- MF:
- C16H17N3O4S
- MW:
- 347.39
- Product Categories:
-
- Inhibitors
- Inhibitor
- Mol File:
- 1403764-72-6.mol
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PFI-1 Chemical Properties
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: ≥10mg/mL
- form
- powder
- color
- white to beige
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PFI-1 Usage And Synthesis
Description
PFI 1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. PFI-1 is a selective BET bromodomain inhibitor with activity at BRD2 (IC50 = 98 nM) and BRD4 (IC50 = 220 nM). PFI 1 induces apoptosis and G1 cell cycle arrest in BET inhibitor-sensitive cell lines (MV4;11). PFI 1 also downregulates Aurora B expression in MV4;11 cells.
Uses
PFI-1 is used as a selective protein interaction inhibitor targetting BET bromodomains, used as regulators required for efficient expression of several growth promoting and anti-apoptotic genes.
Definition
ChEBI: 2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide is a member of quinazolines.
storage
Store at RT
PFI-1Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
Adamas Reagent, Ltd.
- Tel
- 400-6009262 16621234537
- chenyj@titansci.com
Chemsky（shanghai）International Co.,Ltd.
- Tel
- 021-50135380
- shchemsky@sina.com
Jinan Trio PharmaTech Co., Ltd.
- Tel
- +86 (531) 88811783
- sales@trio-pharmatech.com (International market)