4-Difluoromethoxy-3-hydroxybenzaldehyde CAS#: 151103-08-1

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4-Difluoromethoxy-3-hydroxybenzaldehyde

Basic information Safety Supplier Related

4-Difluoromethoxy-3-hydroxybenzaldehyde Basic information

Product Name:

4-Difluoromethoxy-3-hydroxybenzaldehyde

Synonyms:

2-(Difluoromethoxy)-5-formylphenol, alpha,alpha-Difluoro-4-formyl-2-hydroxyanisole
Benzaldehyde,4-(difluoroMethoxy)-3-hydroxy-
Roflumilast impurity 19
3-Hydroxy-4-diflouromethylbenzaldehyde
4-(Difluoromethoxy)-3-hydroxybenzaldehyde 97%
4-(Difluoromethoxy)-3-hydroxybenzaldehyde97%
3-hydroxy-4-difluoroMethoxy benzaldehyde
4-DIFLUOROMETHOXY-3-HYDROXYBENZALDEHYDE

CAS:

151103-08-1

MF:

C8H6F2O3

MW:

188.13

EINECS:

687-745-0

Product Categories:

Roflumilast interemdiate
Aromatics
Aldehydes
Phenyls & Phenyl-Het
Phenyls & Phenyl-Het
Intermediates
Intermediate

Mol File:

151103-08-1.mol

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4-Difluoromethoxy-3-hydroxybenzaldehyde Chemical Properties

Melting point:: 85-90°C
Boiling point:: 280.6±35.0 °C(Predicted)
Density: 1.395±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 7.85±0.35(Predicted)
color: White
InChI: InChI=1S/C8H6F2O3/c9-8(10)13-7-2-1-5(4-11)3-6(7)12/h1-4,8,12H
InChIKey: ZLIKNROJGXXNJG-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=C(OC(F)F)C(O)=C1
CAS DataBase Reference: 151103-08-1(CAS DataBase Reference)

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Safety Information

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-51-22
Safety Statements: 26-36/37/39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2913000090

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4-Difluoromethoxy-3-hydroxybenzaldehyde Usage And Synthesis

Description

4-Difluoromethoxy-3-hydroxybenzaldehyde is an organofluorine compound, mainly used as an intermediate in organic synthesis. It is used in the synthesis of the impurity N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-3-hydroxybenzamide isolated from roflumilast crude^[1].

Chemical Properties

4-Difluoromethoxy-3-hydroxybenzaldehyde is white powder

Uses

4-Difluoromethoxy-3-hydroxybenzaldehyde is a phenyl alkyl ketone derivative used in the preparation of phosphodiesterase-4 (PDE4) inhibitors.

References

[1] YAN LIN. Isolation, synthesis and structure confirmation of the impurity in crude roflumilast product[J]. Research on Chemical Intermediates, 2012. DOI:10.1007/s11164-012-0823-3.

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