TiMolol IMpurity E Chemical Properties

Boiling point:

618.1±55.0 °C(Predicted)

Density 

1.300±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

2.31±0.25(Predicted)

Appearance

White to off-white Solid

Major Application

pharmaceutical (small molecule)

InChI

1S/C17H26N4O6S/c1-17(2,3)18-10-12(27-14(24)5-4-13(22)23)11-26-16-15(19-28-20-16)21-6-8-25-9-7-21/h4-5,12,18H,6-11H2,1-3H3,(H,22,23)/b5-4-/t12-/m0/s1

InChIKey

MGIAXRFZDNBKRF-RXNFCKPNSA-N

SMILES

[s]1nc(c(n1)OC[C@@H](OC(=O)\C=C/C(=O)O)CNC(C)(C)C)N2CCOCC2

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

TiMolol IMpurity E Usage And Synthesis

Uses

1-[(1S)-1-[[(1,1-Dimethylethyl)amino]methyl]-2-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]ethyl] Ester (2Z)-2-Butenedioic Acid (Timolol EP Impurity E; Timolol BP Impurity E; Timolol USP Related Compound E) is an impurity of Timolol (T4437005), an adrenergic blocking agent (1); antiarrhythmic (class II); antianginal; antiglaucoma (2) and antihypertensive (3) agent.

TiMolol IMpurity E(1026075-53-5)Related Product Information

• Bicyclo[3.2.0]hept-3-ene-6-acetic acid, 6-(aminomethyl)-3-ethyl-, 1,1-dimethylethyl ester, (1R,5S,6S)-
• ((1S,5R,6R)-6-Aminomethyl-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid tert-butyl ester
• Timolol EP Impurity G
• Timolol EP Impurity H
• 3-Chloro-4-morpholino-1,2,5-thiadiazole
• (+)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
• (S)-Timolol maleate
• 4-MORPHOLIN-4-YL-1,2,5-THIADIAZOL-3-OL
• 1-Propanol,3-[(1,1-dimethylethyl)amino]-2-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]-oxy]-
• Timolol