3,5-Dimethoxyphenol Chemical Properties

Melting point:

40-43 °C (lit.)

Boiling point:

172-175 °C/17 mmHg (lit.)

Density 

1.1690 (rough estimate)

refractive index 

1.4745 (estimate)

Flash point:

173 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

pka

pK1:9.345 (25°C)

form 

Liquid

color 

Clear colorless to orange-red to pale pink-brownish

Water Solubility 

Soluble in methanol, ethanol, benzene, water (slightly), and chloroform.

Sensitive 

Air & Light Sensitive

BRN 

1239156

InChIKey

XQDNFAMOIPNVES-UHFFFAOYSA-N

LogP

1.640

CAS DataBase Reference

500-99-2(CAS DataBase Reference)

NIST Chemistry Reference

Phenol, 3,5-dimethoxy-(500-99-2)

EPA Substance Registry System

Phenol, 3,5-dimethoxy- (500-99-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

F 

10

Hazard Note 

Irritant

HS Code 

29095090

MSDS

• Language:English Provider:Phloroglucinol dimethyl ether
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3,5-Dimethoxyphenol Usage And Synthesis

Chemical Properties

slightly pink to yellow crystalline powder

Uses

3,5-dimethoxyphenol is a marker for poisoning from Taxus baccata.

Uses

3,5-Dimethoxyphenol is a phenol derivative as antinitrosating agent.

Definition

ChEBI: 3,5-Dimethoxyphenol is a member of methoxybenzenes and a member of phenols.

Synthesis

Ethanethiol (1.25g, 1.5 ml, 0.02 mole) dissolved in N, N- dimethyl-formamide (20 ml) is added to a suspension of sodium hydride (1 g of 50%oil dispersion) in dry DMF (10 ml) under an atmosphere of nitrogen. The mixture is stirred for 5 min under anhydrous conditions. A solution of phloroglucinol trimethyl ether (1.14) (1 g,0.006 moles) in dry DMF (10 ml)is added, and the mixture is refluxed for 3 hr. The reaction mixture is cooled and acidified with hydrochloric acid (10%). It is extracted with ether(3 x 50 ml). The ether extract is washed with water and extracted with sodium hydroxide solution (5%). The clear alkaline extract is acidified with hydrochloric acid. The mixture is extracted with ether. The ether extract is washed with water, ried (anhydrous sodium sulphate), and drilled. 3,5-Dimethoxyphenol is obtained as an oil. Yield 0.9 g (98.1%).B.p.198-199°/30 mm.

Purification Methods

Purify the phenol by distillation followed by sublimation in a vacuum. [Beilstein 6 IV 7362.]

3,5-Dimethoxyphenol(500-99-2)Related Product Information

• 2-Ethoxyphenol
• Dimethyl sulfate
• Metformin
• Diphenyldimethoxysilane
• 1,1-Dimethoxyethane
• Phloroglucinol
• Dimethyl carbonate
• Dimethyl sulfoxide
• Dimethyl sulfide
• 3-Methoxyphenol
• Dimethyldimethoxysilane
• N,N-Dimethylformamide
• Guaiacol
• ETHANE
• Dimethyl fumarate
• Dacthal
• Dimethyl ether
• Dimethyl sebacate