BIBF 1202 Chemical Properties

Melting point:

>216°C (dec.)

Boiling point:

759.5±60.0 °C(Predicted)

Density 

1.331±0.06 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Aqueous Base (Slightly, Heated)

pka

3.94±0.20(Predicted)

form 

Solid

color 

Light Yellow to Yellow

BIBF 1202 Usage And Synthesis

Description

BIBF 1202 is an active metabolite of the VEGFR, FGFR, and PDGFR inhibitor BIBF 1120 (nintedanib; ). It is formed from BIBF 1120 by intracellular esterases. BIBF 1202 inhibits VEGFR2 with an IC₅₀ value of 62 nM.

Uses

Nintedanib Carboxylic Acid is a related compound of Intedanib (I666650), an indolinone derivative that inhibits angiokinase and an antitumor agent.

References

[1] FRANK HILBERG. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.[J]. Cancer research, 2008, 68 12: 4774-4782. DOI: 10.1158/0008-5472.can-07-6307
[2] DAN LIN . Simultaneous determination of nintedanib and its metabolite by UPLC–MS/MS in rat plasma and its application to a pharmacokinetic study[J]. Journal of pharmaceutical and biomedical analysis, 2016, 117: Pages 173-177. DOI: 10.1016/j.jpba.2015.08.024

BIBF 1202(894783-71-2)Related Product Information

• Nintedanib
• N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
• N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide
• 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID ETHYL ESTER
• (Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
• 1-Chloro-4-(trimethoxymethyl)benzene
• Methyl 4-chloro-3-nitrobenzoate
• 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE
• 4'-Amino-N-methylacetanilide
• Ethanesulfonic acid ethyl ester
• (3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic Acid Methyl Ester
• N-(4-aMinophenyl)-2-chloro-N-MethylacetaMide
• 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID
• (Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
• Methyl 1-acetyl-2-oxoindoline-6-carboxylate
• Nintedanib Impurity 15
• P-ANISALDEHYDE DIMETHYL ACETAL
• Methyl oxindole-5-carboxylate