Carboxyethylgermanium sesquioxide Chemical Properties

Melting point:

320°C

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

Aqueous Base (Sparingly)

pka

3.6(at 25℃)

form 

Solid

color 

White to Off-White

Specific Gravity

1.280

Odor

wh. odorless powd.

Water Solubility 

Slightly soluble in water.

Hydrolytic Sensitivity

4: no reaction with water under neutral conditions

Merck 

14,7795

InChIKey

XEABSBMNTNXEJM-UHFFFAOYSA-N

CAS DataBase Reference

12758-40-6(CAS DataBase Reference)

EPA Substance Registry System

2-(Carboxyethyl)germanium sesquioxide (12758-40-6)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

WGK Germany 

2

RTECS 

UA2459750

TSCA 

Yes

HS Code 

2931.90.9051

Toxicity

LD50 i.p. in mice: 2.8 g/kg (Brutkiewicz)

MSDS

• Language:English Provider:3,3'-(1,3-Dioxo-1,3-digermoxanediyl)dipropionic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Carboxyethylgermanium sesquioxide Usage And Synthesis

Description

Propagermanium, the first organogermanium compound marketed as a pharmaceutical, is indicated for the oral treatment of chronic hepatitis B. Propagermanium is reported to enhance production of interferon α/β in virus infected mice and in human peripheral blood mononuclear cells but does not inhibit the growth of various DNA or RNA viruses in vitro. Therefore, enhancement of the host immune system against virus infection was proposed to be responsible for its antiviral activity. Propagermanium also exhibits potent antitumor activity, reportedly via stimulation of T lymphocytes to produce a lyrnphokine (s), possibly interferon-y, which induces the generation and activation of cytotoxic macrophages leading to elimination of tumor cells. Propagermanium has been reported to regulate calcium metabolism and to alleviate cancerous pain and osteocope.

Originator

Sanwa Kagaku (Japan)

Uses

A bifunctional metalloligand with metal-C (Ge-C) bonds,bis(carboxyethylgermanium) sesquioxide, has been used to make two metal-organometallic frameworks (MOMFs). bis-(carboxyethylgermanium)sesquioxide is a as a promising anti-oxidative agent. Bis(carboxyethylgermanium) sesquioxide induce INF-γ and has undergone clinical trials with promising preclinical results.

Uses

Bis(2-carboxyethylgermanium(IV) sesquioxide) can be used as a precursor in the preparation of photoluminescent carbon dots, applicable as fluorescent probes in bioimaging applications.

Uses

antifungal and antiseptic

Definition

ChEBI: Propagermanium is an organogermanium compound.

brand name

Serosion

General Description

Bis(2-carboxyethylgermanium(IV) sesquioxide), also known as repagermanium, is a water-soluble organogermanium compound that exhibits immunostimulatory properties. It is also used as an ingredient in food and cosmetics.

Safety Profile

Moderately toxic by intravenous route. Experimental reproductive effects. See also GERMANIUM COMPOUNDS.

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