3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine
3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine Basic information
- Product Name:
- 3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine
- Synonyms:
-
- m-PEG11-amine
- 3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine
- 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
- mPEG11-NH2/3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine
- CAS:
- 854601-60-8
- MF:
- C23H49NO11
- MW:
- 515.64
- Product Categories:
-
- peg
- Mol File:
- 854601-60-8.mol
3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine Chemical Properties
- Boiling point:
- 551.9±45.0 °C(Predicted)
- Density
- 1.070±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, protect from light
- form
- Solid-Liquid Mixture
- pka
- 8.74±0.10(Predicted)
- color
- Colorless to off-white
3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine Usage And Synthesis
Description
m-PEG11-amine is a water soluble PEG linker containing an amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases solubility in aqueous media.
Biological Activity
M-PEG11-Amino is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker that can be used for PROTAC synthesis.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins