RGFP966 Chemical Properties

Boiling point:

630.4±55.0 °C(Predicted)

Density 

1.19±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 20mg/mL, clear

form 

powder

pka

11.58±0.70(Predicted)

color 

white to beige

InChI

1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+

InChIKey

BLVQHYHDYFTPDV-VCABWLAWSA-N

SMILES

NC1=CC(F)=CC=C1NC(/C=C/C(C=N2)=CN2C/C=C/C3=CC=CC=C3)=O

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

RGFP966 Usage And Synthesis

Uses

RGFP966 is a histone deacetylase 3 (HDAC3) inhibitor.

Definition

ChEBI: N-(2-amino-4-fluorophenyl)-3-[1-(3-phenylprop-2-enyl)-4-pyrazolyl]-2-propenamide is an aromatic amide and an aromatic amine.

Biochem/physiol Actions

RGFP966 changes signal-specific primary auditory cortical plasticity. It is highly effective in cardiomyopathy-associated pathologies.

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