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(-)-Syringaresinol

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(-)-Syringaresinol Basic information

Product Name:
(-)-Syringaresinol
Synonyms:
  • Phenol, 4,4'-[(1R,3aS,4R,6aS)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[2,6-dimethoxy-
  • (-)-Lirioresinol B
CAS:
6216-81-5
MF:
C22H26O8
MW:
418.44
Mol File:
6216-81-5.mol
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(-)-Syringaresinol Chemical Properties

Melting point:
198-199℃
form 
Solid
color 
White to off-white
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(-)-Syringaresinol Usage And Synthesis

Uses

(-)-Syringaresinol, is the isoform of Syringaresinol (HY-N8307), which can be found in stems of Annona Montana, possesses anti-cancer activity. Syringaresinol is an activator of NO synthase phosphorylation and induces vasodilation. Syringaresinol also inhibits the NF-κB pathway and exerts anti-inflammatory activity[1][2][3].

Definition

ChEBI: (-)-syringaresinol is the (7beta,7'beta,8beta,8'beta)-stereoisomer of syringaresinol. It is an enantiomer of a (+)-syringaresinol.

References

[1] Chung BH, et al. Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase. Exp Mol Med. 2012 Mar 31;44(3):191-201. DOI:10.3858/emm.2012.44.3.014
[2] Wang X, et al. Syringaresinol attenuates osteoarthritis via regulating the NF-κB pathway. Int Immunopharmacol. 2023 May;118:109982. DOI:10.1016/j.intimp.2023.109982
[3] Y C Wu, et al. Bioactive constitutents from the stems of Annona Montana. Planta Med. 1995 Apr;61(2):146-9. DOI:10.1055/s-2006-958035

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