Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Inhibitors >  Epigenetics >  Histone Acetyltransferase inhibitors >  ReModelin hydrobroMide

ReModelin hydrobroMide

Basic information Safety Supplier Related

ReModelin hydrobroMide Basic information

Product Name:
ReModelin hydrobroMide
Synonyms:
  • ReModelin hydrobroMide
  • Remodelin HBR
  • 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile, hydrobromide (1:1)
  • Remodelin 16066 Remodelin (hydrobromide) 4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
  • Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-, hydrobromide (1:1)
  • CS-1751
  • 4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
  • ReModelin hydrobroMide USP/EP/BP
CAS:
1622921-15-6
MF:
C15H15BrN4S
MW:
363.2754
Product Categories:
  • Inhibitors
  • ReModelin
Mol File:
1622921-15-6.mol
More
Less

ReModelin hydrobroMide Chemical Properties

storage temp. 
Store at -20°C
solubility 
≥36.3 mg/mL in DMSO; insoluble in H2O; ≥2.6 mg/mL in EtOH with ultrasonic
form 
Powder
color 
Light yellow to yellow
More
Less

ReModelin hydrobroMide Usage And Synthesis

Uses

Remodelin acts as a potent acetyl-transferase NAT10 inhibitor, which is shown to correct defects of laminopathic cells. Anti-aging.

Biological Activity

remodelin is a potent inhibitor of nat10 [1].n-acetyltransferase 10 (nat10) is the only identified lysine acetyltransferase that acts on microtubules and histones [1]. nat10 mainly exists in the nucleolus.remodelin is a potent nat10 inhibitor. in lamin a/c depletion (silmna) cells, remodelin remodeled nuclear architecture through inhibition of nat10 lysine acetyltransferase activity. in cells derived from lmna-mutated hgps patients and primary mrc5 fibroblasts aged in culture, remodelin significantly decreased the prevalence of misshapen nuclei. in u2os cells and normal fibroblasts, remodelin inhibited nuclear shape defects induced by farnesyltransferase inhibitors (fti). in hgps cells, remodelin reduced the amount of misshapen nuclei, suggesting that inhibition of nat10 mediated nuclear shape normalization. also, remodelin reduced dna damage signaling, reduced sun1 accumulation at the nuclear envelope, reduced the levels of autophosphorylated atm and dna double-strand break markers γh2ax, and improved chromatin and nucleolar organization. in silmna and hgps cells, remodelin inhibited microtubule anchorage to centrosomes [1].

References

[1]. larrieu d, britton s, demir m, et al. chemical inhibition of nat10 corrects defects of laminopathic cells. science, 2014, 344(6183): 527-532.

ReModelin hydrobroMideSupplier

Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Email
info@chemexpress.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Email
info@adooq.cn
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Email
sales@letopharm.com
More
Less

ReModelin hydrobroMide(1622921-15-6)Related Product Information