(2,4-diMethylphenyl)(2-nitrophenyl)sulfane Chemical Properties

Boiling point:

353.9±30.0 °C(Predicted)

Density 

1.24±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

Appearance

Light yellow to yellow Solid

(2,4-diMethylphenyl)(2-nitrophenyl)sulfane Usage And Synthesis

Uses

(2,4-Dimethylphenyl)(2-nitrophenyl)sulfane is a reacatnat in studying generic industry approach to efficient purification of potential mutagenic impurities in the synthesis of drug substances.

Synthesis

Dissolve 50.00 g (0.36 mol) of 2,4- dimethylbenzenethiol (5) in 300 mL of DMF, add 30.44 g () of potassium hydroxide and stir at room temperature. 0.5425mol) of potassium hydroxide, stir at room temperature, add a total of 56.99 g (0.3617 mol) of o-chloronitrobenzene (6) in 3 batches, and react at 50 . The reaction was carried out at 50 for 5 h. The reaction was monitored by thin-layer chromatography (TLC), and the unfolding reagent was [ ethyl acetate: petroleum ether (AR bp: 60 ~90 )=1:5] . The reaction was monitored by TLC. After the reaction was completed and cooled to room temperature, 900 mL of distilled water was added with thorough stirring, a large amount of solid was precipitated, and the filter cake was filtered and recrystallized with ethanol to obtain 89.10 g of compound 4. Yield 95%, mp: 98.0%. 95%, mp: 98 ~100 , MS: C 14 H 13 NO 2 S [M+Na] + 282.0563 .

(2,4-diMethylphenyl)(2-nitrophenyl)sulfane(1610527-49-5)Related Product Information

• Vortioxetine Impurity 37 HCl
• 2,4-DIMETHYLDIPHENYLSULFIDE
• Vortioxetine impurity S
• 1-[2-[(2,4-diMethylphenyl)sulfinyl]phenyl]- Piperazine
• 1-(2-BROMOPHENYL)PIPERAZINE
• 2,5-DIMETHYLTHIOPHENOL
• 1-[2-[(3,4-diMethylphenyl)thio]phenyl]- Piperazine
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• 2,4-Dimethylbenzenethiol
• BIS(2-BROMOETHYL)AMINE HYDROBROMIDE
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• di(2,4-xylyl) disulphide
• Vortioxetine
• 1-[2-[(5-chloro-2,4-diMethylphenyl)thio]phenyl]- Piperazine
• Vortioxetine Impurity 21
• 3,4-DIMETHYLTHIOPHENOL
• Vortioxetine Impurity 25