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Nimustine hydrochloride

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Nimustine hydrochloride Basic information

Product Name:
Nimustine hydrochloride
Synonyms:
  • 1-(4-AMINO-2-METHYL-5-PYRIMIDINYL)-METHYL-3-(2-CHLOROETHYL)-3-NITROSOUREA HYDROCHLORIDE
  • ACNU
  • Nimustine HCl(ACNU)
  • NIMUSTINE HCL
  • NIMUSTINE HYDROCHLORIDE
  • N'-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-N-(2-CHLOROETHYL)-N-NITROSOUREA HYDROCHLORIDE
  • 1-(2-cloroetil)-1-nitroso-3-((2-metil-4-aminopirimidin-5-il)metil)ureaclorhi
  • 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosoureahydr
CAS:
55661-38-6
MF:
C9H14Cl2N6O2
MW:
309.15
EINECS:
678-313-2
Product Categories:
  • Anti-cancer&immunity
  • Antitumors for Research and Experimental Use
  • Biochemistry
Mol File:
55661-38-6.mol
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Nimustine hydrochloride Chemical Properties

Melting point:
186°C(lit.)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
soluble in Methanol
form 
White to light yellow crystalline solid.
color 
White to Light yellow
PH
3.0~4.5 (5g/l, 25℃)
Merck 
14,6553
CAS DataBase Reference
55661-38-6(CAS DataBase Reference)
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Safety Information

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
36/37/39-45
RIDADR 
UN 2811
RTECS 
YR8450000
HS Code 
2933.59.8000
HazardClass 
6.1
PackingGroup 
III
Toxicity
LD50 in mice, rats (mg/kg): 62, 46 i.v. (Masuda)
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Nimustine hydrochloride Usage And Synthesis

Uses

Nimustine Hydrochloride is a DNA alkylator and cross-linking agent. It is used in chemotherapy in a part of anti-cancer cocktail used to treat malignant melanoma.

Definition

ChEBI: A hydrochloride obtained by combining nimustine with one equivalent of hydrochloric acid. An antineoplastic agent especially effective against malignant brain tumors.

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