AC-262536 Chemical Properties

Melting point:

158-162°C

Boiling point:

526.0±45.0 °C(Predicted)

Density 

1.28±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: Soluble

pka

14.73±0.20(Predicted)

form 

Solid

color 

White to off-white

InChI

InChI=1/C18H18N2O/c19-11-12-5-8-18(17-4-2-1-3-16(12)17)20-13-6-7-14(20)10-15(21)9-13/h1-5,8,13-15,21H,6-7,9-10H2/t13-,14+,15+

InChIKey

ATKWLNSCJYLXPF-FICVDOATNA-N

SMILES

O[C@H]1C[C@H]2CC[C@H](N2C2=CC=C(C#N)C3C=CC=CC2=3)C1 |&1:1,3,6,r|

Safety Information

WGK Germany 

3

AC-262536 Usage And Synthesis

Uses

AC-262536 is a hydrocarbon organic matter and can be used as pharmaceutical intermediates.

General Description

AC-262536 is a selective nonsteroidal androgen receptor modulator (SARM) with beneficial anabolic effects. AC-262536 has potent agonist activity against androgen receptors with affinity in the low nanomolar range (1-10 nM). It is another novel drug put forth by Acadia, just like ACP-105. It is a SARM by design, as it selectively binds to the androgen receptor, just like all the other SARMs. AC-262536 came into light in 2007 and even though 13 years have passed, little research has been done on this compound.

Biological Activity

AC-262536 exhibits potency at AR similar to that observed for the natural ligand testosterone, 13 nM vs. 2 nM, respectively. Interestingly, AC-262536 behaved as a partial agonist (% Eff 67 ± 9) relative to testosterone. In reporter gene assays, AC-262536 modulated the transcriptional activity of a natural target gene in an AR-dependent manner with low nanomolar potency (2 nM). It displayed partial agonism properties (% Eff 72 ± 9) relative to testosterone. Further, AC-262536 physically interacted with AR with an affinity of 5 nM. Profiling at other nuclear receptors revealed that AC-262536 is extremely selective for AR, having no significant affinity for the other 47 human nuclear receptors, including the steroid receptors estrogen ERs, glucocorticoid GR, mineraloid MR, and progesterone PR, at doses as high as 10M (data not shown)[1].

Side effects

Testosterone Suppression: AC-262536 will suppress your natural testosterone levels. Compared to other SARMs, this suppression of testosterone is rather mild and similar to that of Ostarine and Andarine. Testosterone suppression can manifest in the following symptoms: Lethargy, Lack of motivation, Decreased libido, Weaker erections, Testicular pain, and Testicular atrophy. AC-262536 will cause dyslipidemia. Your HDL will decrease, and your LDL will increase during an AC-262 cycle. The extent of this side effect can be compared to that of similarly strong SARMs. The following side effects can happen to anyone who alters their endocrine balance, regardless of whether they’re taking AC-262 or something else: Gynecomastia: men who had pubertal gyno are at risk of redeveloping it if they take AC-262536; Hair shedding (temporary and completely reversible); Insomnia.

References

[1] Fabrice Piu . “Pharmacological characterization of AC-262536, a novel selective androgen receptor modulator.” Journal of Steroid Biochemistry and Molecular Biology 109 1 (2008): Pages 129-137.