Tolazoline hydrochloride Chemical Properties

Melting point:

172-176 °C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly, Heated), Methanol (Slightly)

form 

Crystalline Powder

color 

White to almost white

Sensitive 

Hygroscopic

Merck 

14,9506

Stability:

Hygroscopic

CAS DataBase Reference

59-97-2(CAS DataBase Reference)

EPA Substance Registry System

Tolazoline hydrochloride (59-97-2)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

22

RIDADR 

2811

TSCA 

Yes

HS Code 

29332900

Toxicity

LD50 orl-rat: 1200 mg/kg NIIRDN 6,511,82

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

Tolazoline hydrochloride Usage And Synthesis

Chemical Properties

Pale Yellow Crystalline Solid

Originator

Priscoline,Ciba,US,1948

Uses

a-adrenergic antagonist. A peripheral vasodilator

Uses

Αn α-adrenergic antagonist. A peripheral vasodilator.

Uses

adrenergic blocker

Definition

ChEBI: Tolazoline hydrochloride is a member of benzenes.

Manufacturing Process

The phenyl-acetiminoether hydrochloride of the formula from 12 parts of benzylcyanide and ethanol and HCl is mixed with 8 parts of ethylenediamine hydrate which has been diluted with little alcohol, whereby the crystals go into solution. The whole is then heated on the water-bath until the ammonia odor has disappeared, cooled, concentrated caustic potash solution added, and the separated oil extracted with ether. The solution is dried with potassium carbonate and potassium hydroxide. After evaporation a pale oil is left which distills at 147°C under a pressure of 9 mm and which solidifies in the condenser to a white crystalline mass. The yield amounts to 90% of the theory. The hydrochloride melts at 168° to 170°C.

brand name

Tolazoline is INN and BAN.

Therapeutic Function

Vasodilator

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: change in heart rate, sweating, ulceration or bleeding from duodeum, ulceration or bleeding from small intestine, unspecified vascular effects. When heated to decomposition it emits very toxic fumes of NO, and HCl.

Veterinary Drugs and Treatments

flipping of lips); piloerection; clear lacrimal & nasal discharge; muscle fasciculations; apprehensiveness Uses/Indications Tolazoline is approved and indicated for the reversal of effects associated with xylazine in horses. It has also been used for this purpose in a variety of other species as well, but less safety and efficacy data is available.
In humans, the primary uses for tolazoline are: treatment of persistent pulmonary hypertension in newborns, adjunctive treatment and diagnosis

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