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PAROMOMYCIN SULFATE

Basic information Safety Supplier Related

PAROMOMYCIN SULFATE Basic information

Product Name:
PAROMOMYCIN SULFATE
Synonyms:
  • PAROMOMYCIN SULFATE
  • PAROMOMYCIN SULFATE SALT
  • PAROMOMYCIN SULPHATE
  • NEOMYCIN E
  • aminosidinesulfate
  • aminosidinesulphate
  • aminosidinsulfate
  • fi5853
CAS:
1263-89-4
MF:
C23H47N5O18S
MW:
713.71
EINECS:
215-031-7
Product Categories:
  • Inhibitors
  • SUPERINONE
  • Agro-Products
  • Amines
  • Intermediates & Fine Chemicals
  • antibiotic
  • L - Z
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  • Chemical Structure Class
  • Genetic Marker SelectionAntibiotics
  • Interferes with Protein SynthesisSpectrum of Activity
  • Mechanism of Action
Mol File:
1263-89-4.mol
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PAROMOMYCIN SULFATE Chemical Properties

Melting point:
145 °C (decomp)
alpha 
D25 +50.5° (c = 1.5 in water pH 6)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: 50 mg/mL store stock solution at 2-8°C. Stable at 37°C for 5 days.
form 
powder
color 
White to Off-White
Water Solubility 
Soluble in water
Merck 
14,7041
BRN 
5715182
Stability:
Hygroscopic
InChIKey
LJRDOKAZOAKLDU-UDXJMMFXSA-N
CAS DataBase Reference
1263-89-4
EPA Substance Registry System
Paromomycin sulfate (1263-89-4)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
23/24/25-36/38-39/23/24/25-61-36/37/38
Safety Statements 
26-36/37-45-38-36
WGK Germany 
2
RTECS 
WK2320000
HS Code 
2941901010
Toxicity
LD50 in mice (mg/kg): ~15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli)

MSDS

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PAROMOMYCIN SULFATE Usage And Synthesis

Description

Paromomycin was found in the culture broth of Streptomyces rimosus forma paromomycinus by Parke Davis & Co. in 1959. In the same year it was found in the culture broth of S. Crestomyceticus by Farmitalia and named amminosidin. Paromomycin is related structurally to neomycin, but it has a hydroxyl group at the 6 position, whereas neomycin has an amino group. Its antibacterial activity is weaker than that of neomycin, but its toxicity is much less. Paromomycin is used by intramuscular injection for therapy of respiratory, urinary, and surgical infections and by oral administration to treat dysentery and salmonellosis.

Chemical Properties

PAROMOMYCIN SULFATE is White to Off-White Solid

Uses

PAROMOMYCIN SULFATE is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed addit ive in turkey poults experimentally infected with Histomonas meleagridis.

Uses

antibacterial, antiamebic

Uses

polymeric nonionic detergent

Definition

ChEBI: An aminoglycoside sulfate salt resulting from the treatment of paromomycin with sulfuric acid. A broad-spectrum antibiotic, it is used for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoa infections. It is also used as a therapeutic against visceral leishmaniasis.

brand name

Humatin (King); Humatin (Parke- Davis).

General Description

Chemical structure: aminoglycoside

Biochem/physiol Actions

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Clinical Use

The isolation of paromomycin (Humatin) was reported in1956 from a fermentation with a Streptomyces sp. (PD04998), a strain said to resemble S. rimosus very closely.The parent organism had been obtained from soil samplescollected in Colombia. Paromomycin, however, moreclosely resembles neomycin and streptomycin in antibioticactivity than it does oxytetracycline, the antibiotic obtainedfrom S. rimosus.
Paromomycin has broad-spectrum antibacterial activityand has been used for the treatment of GI infections causedby Salmonella and Shigella spp., and enteropathogenic E.coli. Currently, however, its use is restricted largely to thetreatment of intestinal amebiasis. Paromomycin is soluble inwater and stable to heat over a wide pH range.

Safety Profile

Poison by intravenous,subcutaneous, and intramuscular routes. Mildly toxic byingestion. Mutation data reported. When heated to decomposition it emits very toxic fumesof SOx and NOx.

Purification Methods

Purify it by dissolving it in H2O (0.5g/10mL) and adding excess EtOH, filter or collect and wash with EtOH, then Et2O by centrifugation, and dry it in vacuo. An aqueous solution is stable at 37o for a week but longer at 0-5o. The free base [7542-37-2] is a white amorphous powder which should be stored under N2 because it is strongly basic and can absorb CO2 from the atmosphere. It is soluble in MeOH (less soluble in EtOH) and has [] D 25 +65o (c 1.5, MeOH). It is an antimicrobial against Gram +ve and Gram –ve bacteria and is antiamoebic. It inhibits initiation and peptide elongation during protein synthesis. [Haskell et al. J Am Chem Soc 8 1 , 3480, 3482 1959, Hichens & Rinehart J Am Chem Soc 85 1547 1963, Beilstein 18 III/IV 7534.]

PAROMOMYCIN SULFATESupplier

Hubei Weideli Chemical Reagent Co.,Ltd. Gold
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13339985473
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C13339985473@163.com
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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3B Pharmachem (Wuhan) International Co.,Ltd.
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TCI (Shanghai) Development Co., Ltd.
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Beijing HwrkChemical Technology Co., Ltd
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010-89508211 18501085097
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