2-(2'-BROMOPHENOXY)PROPANE Chemical Properties

Boiling point:

73 °C / 2mmHg

Density 

1.34

refractive index 

1.5360-1.5400

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow

Water Solubility 

Slightly soluble in water.

CAS DataBase Reference

701-07-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

2909309090

2-(2'-BROMOPHENOXY)PROPANE Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

1-Bromo-2-isopropoxybenzene is used as an intermediate in organic syntheses.

Synthesis

General procedure for the synthesis of 1-bromo-2-isopropoxybenzene from 2-bromophenol and 2-bromopropane: A mixture of 2-bromophenol (1.156 mmol), anhydrous K2CO3 (1.20 eq., 192 mg), sodium iodide (4 mg), and anhydrous ethanol (3 mL) was magnetically stirred at room temperature under argon protection. 2-Bromopropane (1.20 eq.) was added slowly and the mixture was then refluxed for 5 hours. After the reaction was complete, it was cooled to room temperature and the solvent was removed under reduced pressure. Ethyl acetate (50 mL) was added to dissolve the residue and the organic phase was washed sequentially with 1M NaOH and brine (15 mL each). The organic phase was dried with anhydrous Na2SO4 and the solvent was evaporated under reduced pressure to obtain the crude product. Finally, the crude product was purified by fast column chromatography.

References

[1] Journal of Organic Chemistry, 2000, vol. 65, # 26, p. 9143 - 9151
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 12, p. 1997 - 2009
[3] Organic Preparations and Procedures International, 2015, vol. 47, # 3, p. 227 - 231
[4] Patent: WO2009/55674, 2009, A1. Location in patent: Page/Page column 59
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 9, p. 4189 - 4204

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