Phenformin hydrochloride Chemical Properties

Melting point:

175-178°C

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

Methanol (Slightly), Water (Slightly)

color 

White to Off-White

Water Solubility 

>=10 g/100 mL at 21 ºC

CAS DataBase Reference

834-28-6(CAS DataBase Reference)

EPA Substance Registry System

Phenformin hydrochloride (834-28-6)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

WGK Germany 

3

RTECS 

DU2200000

HS Code 

29252900

Toxicity

LD50 in mice (mg/kg): 19 i.v., 450 orally; in rats: 1050 orally; in guinea pigs: 47 orally, 19 s.c. (Proske)

MSDS

• Language:English Provider:1-Phenethylbiguanide hydrochloride
• Language:English Provider:SigmaAldrich

Phenformin hydrochloride Usage And Synthesis

Description

Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus. In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling. Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently. Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.

Chemical Properties

White Crystalline Solid

Uses

erectile dysfunction therapy

Uses

It is an anti-diabetic drug from the biguanide class.

brand name

DBI (Ciba-Geigy).

General Description

White solid or powder. Formerly used as an anti-diabetic drug. Toxic (causes lactic acidosis.

Air & Water Reactions

Water soluble.

Reactivity Profile

Phenformin hydrochloride gives weakly acidic aqueous solutions. May react with strong oxidizing agents.

Fire Hazard

Flash point data for Phenformin hydrochloride are not available; however, Phenformin hydrochloride is probably combustible.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx.

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