trans-caffeic acid Chemical Properties

Melting point:

211-213 °C (dec.)(lit.)

Boiling point:

416.8±35.0 °C(Predicted)

Density 

1.478±0.06 g/cm3(Predicted)

solubility 

ethanol: 50 mg/mL

form 

powder

pka

4.58±0.10(Predicted)

color 

yellow to tan

BRN 

1954563

LogP

1.420 (est)

CAS DataBase Reference

501-16-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-40-63-68-36

Safety Statements 

26-36/37/39-36/37

WGK Germany 

3

RTECS 

GD8950000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

trans-caffeic acid Usage And Synthesis

Uses

trans-Caffeic Acid is a useful synthetic intermediate. It was used as a reactant to synthesize N-caffeoylphenalkylamide derivatives as bacterial efflux pump inhibitors. It is also used to prepare caffeic acid phenethyl ester analogs with antitumor structures.

Chemical Properties

Pale yellow crystalline powder

Uses

trans-Caffeic Acid is a useful synthetic intermediate. It was used as a reactant to synthesize N-caffeoylphenalkylamide derivatives as bacterial efflux pump inhibitors. It is also used to prepare caffeic acid phenethyl ester analogs with antitumor structures.

Definition

ChEBI: Caffeic acid is a hydroxycinnamic acid that is cinnamic acid in which the phenyl ring is substituted by hydroxy groups at positions 3 and 4. It exists in cis and trans forms; the latter is the more common. It has a role as a plant metabolite, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor, an EC 2.5.1.18 (glutathione transferase) inhibitor, an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor, an antioxidant and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a hydroxycinnamic acid and a member of catechols.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

trans-caffeic acid(501-16-6)Related Product Information

• p-Coumaric acid
• 12-HYDROXYSTEARIC ACID
• 4-Methylcinnamic acid
• Caffeic acid