Basic information Safety Supplier Related

IRL-2500

Basic information Safety Supplier Related

IRL-2500 Basic information

Product Name:
IRL-2500
Synonyms:
  • IRL-2500
  • N-3-[1,1'-BIPHENYL]-4-YL-N-(3,5-DIMETHYLBENZOYL)-N-METHYL-D-ALANYL-L-TRYPTOPHAN
  • L-Tryptophan, 3-[1,1'-biphenyl]-4-yl-N-(3,5-dimethylbenzoyl)-N-methyl-D-alanyl-
  • ((R)-3-([1,1'-Biphenyl]-4-yl)-2-(N,3,5-trimethylbenzamido)propanoyl)-L-tryptophan
  • IRL 2500, 10 mM in DMSO
CAS:
169545-27-1
MF:
C36H35N3O4
MW:
573.68
Product Categories:
  • Endothelin receptor
Mol File:
169545-27-1.mol
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IRL-2500 Chemical Properties

Boiling point:
893.7±65.0 °C(Predicted)
Density 
1.246±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble to 100 mM in 1eq. NaOH
form 
Powder
pka
3.34±0.10(Predicted)
color 
White to light yellow
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IRL-2500 Usage And Synthesis

Uses

IRL 2500 is a potent endothelin ETB selective antagonist.

Biological Activity

Potent endothelin receptor antagonist; shows some selectivity for ET B receptors (IC 50 values are 1.3 and 94 nM for ET B and ET A receptors respectively). Inhibits ET B receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo .

in vivo

IRL 2500 (intravenous injection;10 mg/kg) inhibits the initial transient decrease in mean arterial pressure (MAP) induced by the ETB-selective agonist IRL 1620 in rats, IRL 2500 also attenuates the IRL 1620-mediated increase in renal vascular resistance (RVR) in the anesthetized rat[1]. IRL 2500 (intravenous injection;10 mg/kg) pre-reatment significantly reduces the initial vasodepressor response to endothelin-1 (ET-1) and IRL 1620, however, it is not alters the secondary and sustained pressor response to these agonists[2].

IC 50

ETB: 1.3 nM (IC50); ETA: 94 nM (IC50)

storage

Desiccate at RT

IRL-2500Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Email
info@adooq.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Email
Sales@ATKchemical.com
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IRL-2500(169545-27-1)Related Product Information