2-Bromo-4-chloropyridine Chemical Properties

Melting point:

<30℃

Boiling point:

98°C

Density 

1.736±0.06 g/cm3(Predicted)

Flash point:

>110℃

storage temp. 

-20°C

solubility 

soluble in Methanol

form 

powder to lump to clear liquid

pka

0.12±0.10(Predicted)

color 

White or Colorless to Almost white or Almost colorless

InChIKey

SURKZMFXICWLHU-UHFFFAOYSA-N

CAS DataBase Reference

22918-01-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-41-37/38-22

Safety Statements 

26-36/37/39-39

WGK Germany 

1

HS Code 

2933399990

2-Bromo-4-chloropyridine Usage And Synthesis

Chemical Properties

Light yellow liquid

Uses

2-Bromo-4-chloropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

To an aqueous solution of 48 % strength hydrobromic acid (82 rnL) at 0 0C was added 4-chloro-2-pyridinamine (8.9 g, 69.2 mmol) followed by addition of bromine (33.4 g, 209 mmol) over 10 min. The resulting mixture was cooled to -10 0C, and a solution of NaNO2 (10.65 g, 154 mmol) in H2O (20 rnL) was poured over 30 min. The mixture was warmed at room temperature and stirred overnight. The mixture was cooled to 0 0C, and NaOH (35 %) was added until the pH >10. The mixture was then extracted with ethyl acetate. The organic layer was then dried, filtered, and concentrated in vacuo. The product was purified via column chromatography (0-20 per cent ethyl acetate/hexane) to afford 2-bromo-4-chloropyridine (12.1 g, 92 %).

2-Bromo-4-chloropyridine(22918-01-0)Related Product Information

• 2-Chloro-5-chloromethylpyridine
• 2-Chloro-3-hydroxypyridine
• 1-Hexadecylpyridinium bromide
• Clopidol
• Pentachloropyridine
• 2-Bromopyridine
• 2-Bromo-5-nitropyridine
• 4-Chloropyridinium chloride
• 5-Amino-2-bromo-3-chloropyridine
• 3-AMINO-2-BROMO-5-CHLOROPYRIDINE
• 2-BROMO-3-CHLOROPYRIDINE
• 2-Bromo-6-fluorotoluene
• 2-Bromo-5-fluorophenol
• 2-BROMO-5-METHOXYBENZONITRILE
• 2-Bromo-3,5-dichloropyridine
• 1-(6-BROMO-PYRIDIN-3-YL)-ETHANONE
• 2-bromo-5-methyl-phenol
• 2-Bromo-6-fluorobenzoic acid