Sulfamethazine sodium salt
Sulfamethazine sodium salt Basic information
- Product Name:
- Sulfamethazine sodium salt
- Synonyms:
-
- (n(sup1)-(4,6-dimethyl-2-pyrimidinyl)sulfanilamido)-sodiu
- 4-amino-n-(4,6-dimethyl-2-pyrimidinyl)-benzenesulfonamidmonosodiumsalt
- sodiumsulphamezathine
- sulfamethazinesodium
- sulmet
- vesadin
- 4-AMINO-N-[4,6-DIMETHYL-2-PYRIMIDINYL]BENZENE-SULFONAMIDE SODIUM SALT
- SULFADIMIDINE SODIUM
- CAS:
- 1981-58-4
- MF:
- C12H15N4NaO2S
- MW:
- 302.33
- EINECS:
- 217-840-0
- Product Categories:
-
- Animal medication
- Inhibitors
- API
- sulfonamides
- Pharmaceutical intermediate
- Antibiotics for Research and Experimental Use
- Biochemistry
- Sulfonamides (Antibiotics for Research and Experimental Use)
- 1981-58-4
- Mol File:
- 1981-58-4.mol
Sulfamethazine sodium salt Chemical Properties
- Melting point:
- >288°C (dec.)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- H2O: soluble50mg/mL
- form
- powder
- color
- white to off-white
- Water Solubility
- H2O: soluble 50mg/mL
- Merck
- 14,8915
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C12H14N4O2S.Na.H/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11;;/h3-7H,13H2,1-2H3,(H,14,15,16);;
- InChIKey
- WIVZAHIZHZEEOX-UHFFFAOYSA-N
- SMILES
- S(C1C=CC(N)=CC=1)(=O)(=O)NC1=NC(C)=CC(C)=N1.[NaH]
- CAS DataBase Reference
- 1981-58-4
- EPA Substance Registry System
- Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-, monosodium salt (1981-58-4)
MSDS
- Language:English Provider:SigmaAldrich
Sulfamethazine sodium salt Usage And Synthesis
Chemical Properties
White or milky white crystalline powder, odorless or almost odorless, easily soluble in water, slightly soluble in ethanol.
Uses
Antibacterial;Inhibitor of folic acid synthesis
Biological Activity
Sulfamethazine is an antimicrobial sulfur drug th at blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.
in vivo
Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC0->∞, significantly increases t1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01[1].
| Animal Model: | 19 healthy female pigs (6-week-old, 4.5-6.2 kg)[1] |
| Dosage: | 80 mg/kg |
| Administration: | Intravenous injection (Pharmacokinetic study) |
| Result: | The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC0->∞ were significantly decreased and t1/2α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01. |
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Sulfamethazine sodium salt(1981-58-4)Related Product Information
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