2,4'-Difluorobenzophenone Chemical Properties

Melting point:

22-24 °C(lit.)

Boiling point:

176-178 °C16 mm Hg(lit.)

Density 

1.244 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.5689(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, Methanol

form 

Solid

color 

Off-White

Specific Gravity

1.244

FreezingPoint 

22.0 to 28.0 ℃

BRN 

3268520

InChI

InChI=1S/C13H8F2O/c14-10-7-5-9(6-8-10)13(16)11-3-1-2-4-12(11)15/h1-8H

InChIKey

LKFIWRPOVFNPKR-UHFFFAOYSA-N

SMILES

C(C1=CC=CC=C1F)(C1=CC=C(F)C=C1)=O

CAS DataBase Reference

342-25-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-36/38

Safety Statements 

26-37/39-24/25-37-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29147000

MSDS

• Language:English Provider:2,4'-Difluorobenzophenone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,4'-Difluorobenzophenone Usage And Synthesis

Chemical Properties

clear light yellow liquid after melting

Uses

2,4’-Difluorobenzophenone is a reactant in the synthesis of EP1 receptor antagonists for the treatment of overactive bladder. Also used in the design and synthesis of thiosemicarbazone cathespin L inhibitors.

Synthesis

The general procedure for the synthesis of (2-fluorophenyl)(4-fluorophenyl)methanone from 4-fluorophenylmagnesium bromide and o-fluorobenzoyl chloride was as follows: 2-fluorobenzoyl chloride (6 mmol, 1.0 eq.) was dissolved in 2-methyltetrahydrofuran (15 mL) and transported through the material channel A and the metering pump P1; meanwhile, 4-fluorophenylmagnesium bromide (9 mmol, 1.5 eq.) was dissolved in 2- methyltetrahydrofuran (15 mL), delivered through material channel B and metering pump P2. The two solutions were mixed in the mixing module M at a preset temperature of 25 °C and a flow rate of 1 mL/min, and then entered into the reaction module L for 1 hour. Upon completion of the reaction, the reaction solution flowed out of outlet D and was collected in 1 mol/L hydrochloric acid solution for quenching. The quenched solution was stirred, washed with saturated brine solution, dried with anhydrous sodium sulfate, concentrated and purified by column chromatography to afford the target product (2-fluorophenyl)(4-fluorophenyl)methanone.

References

[1] Patent: CN108409516, 2018, A. Location in patent: Paragraph 0049-0052
[2] Journal of the American Chemical Society, 1947, vol. 69, p. 662

2,4'-Difluorobenzophenone(342-25-6)Related Product Information

• Difloxacin
• 2,4-Dihydroxybenzophenone
• 4,4'-Dihydroxybenzophenone
• 4,4'-Dimethylbenzophenone
• Benzophenone
• 4-Chlorobenzophenone
• (3,4-Diaminophenyl)phenylmethanone
• 3,4-Dihydroxybenzophenone
• 2'-Fluoroacetophenone
• Difluorochloromethane
• 4-Fluorobenzaldehyde
• Benzaldehyde
• 4-Fluoroacetophenone
• 1-ETHYL-4-FLUOROBENZENE
• 4-Fluorobenzophenone
• difluoroethane
• Polyvinylenedifluoride
• p,p'-Difluorobenzophenone,p,p’-difluorobenzophenon