Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Circulatory system drugs >  Antihypertensive drugs >  Terazosin

Terazosin

Basic information Safety Supplier Related

Terazosin Basic information

Product Name:
Terazosin
Synonyms:
  • 1-(4-aMino-6,7-diMethoxy-quinazolin-2-yl)-4-(tetrahydrofuran-2-carbonyl)-piperazine
  • TERAZOSIN(HYTRIN)
  • Prazosin Tetrahydro IMpurity
  • Hytrin:Hytrinex
  • Urodie
  • Vasomet:Vicard
  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl) carbonxyl] piperazine hydrochloride
  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbowl]piperazine
CAS:
63590-64-7
MF:
C19H25N5O4
MW:
387.43
EINECS:
613-265-8
Product Categories:
  • API's
  • API
  • Terazosin
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
63590-64-7.mol
More
Less

Terazosin Chemical Properties

Melting point:
281-283°C
Boiling point:
664.5±65.0 °C(Predicted)
Density 
1.332±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
H2O: 25 mg/mL
form 
powder
pka
pKa (0.1N NaOH): 7.1(at 25℃)
color 
white to off-white
Water Solubility 
30.6mg/L(22.5 ºC)
BCS Class
1/3
InChIKey
VCKUSRYTPJJLNI-UHFFFAOYSA-N
CAS DataBase Reference
63590-64-7(CAS DataBase Reference)
More
Less

Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
TK8044925

MSDS

More
Less

Terazosin Usage And Synthesis

Chemical Properties

White to Off-White Crystalline Powder

Uses

An α-1-adrenergicblocker related to prazosin.

Uses

Terazosin is used for the same indications as is prazosin; however, it has the advantage of being able to be used once a day.

Uses

An a-1-adrenergicblocker related to prazosin

Definition

ChEBI: Terazosin is a member of quinazolines, a member of piperazines, a member of furans and a primary amino compound. It has a role as an antineoplastic agent, an antihypertensive agent and an alpha-adrenergic antagonist.

Clinical Use

Alpha-adrenoceptor blocker:
Hypertension
Benign prostatic hyperplasia (BPH)

Synthesis

Terazosin, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)- piperazine (12.2.13), only differs from prazosin in that the furyl radical is replaced with a tetrahydrofuryl radical. It is synthesized in exactly the same manner except using 1-(2-tetrahydrofuroyl)piperazine instead of 1-(2-furoyl)piperazine [48–51].

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Antidepressants: enhanced hypotensive effect with MAOIs.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect - avoid concomitant use.
Beta-blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Calcium-channel blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Diuretics: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Moxisylyte: possibly severe postural hypotension when used in combination.

Metabolism

Terazosin is metabolised in the liver; one of the metabolites has antihypertensive activity.
Terazosin is excreted in faeces via the bile, and in the urine, as unchanged drug and metabolites.

TerazosinSupplier

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Email
bin.wu@shlschem.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com