(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Chemical Properties

Melting point:

91-93oC

Boiling point:

409.1±0.0 °C(Predicted)

Density 

1.158

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)

pka

8.99±0.10(Predicted)

form 

Solid

color 

White

PH

9.38 at 25℃ and 10.07g/L

Water Solubility 

Soluble in chloroform, methanol, and dichloromethane. Slightly soluble in water.

InChI

InChI=1/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2/t17-/s3

InChIKey

UZKBSZSTDQSMDR-SCBJWRGWNA-N

SMILES

[C@@H](N1CCNCC1)(C1C=CC=CC=1)C1C=CC(Cl)=CC=1 |&1:0,r|

CAS DataBase Reference

300543-56-0

Safety Information

HS Code 

2933599550

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Usage And Synthesis

Uses

Intermediate in the production of (R)-Cetirizine (C281106).

Uses

(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine intermediate in the production of (R)-Cetirizine.

Application

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine could be used to synthesize a series of novel derivatives. Most of these derivatives significantly affected both allergic asthma and allergic itching. Meanwhile, in the test of allergic itching, five of the 19 compounds have more potent activities than levocetirizine[1].

References

[1] Lisheng Wang. “Design, synthesis, and anti-allergic activities of novel (R)(-)-1-[(4-chlorophenyl)phenyl methyl]piperazine derivatives.” Medicinal Chemistry Research 21 1 (2010): 124–132.

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine(300543-56-0)Related Product Information

• (S)-(+)-Epichlorohydrin
• Acetic acid, 2-[2-[2-[4-[(4- chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]ethoxy]-
• Levocetirizine Impurity 4
• Levocetirizine amide impurity HCl
• 1-(o-Chloro-α-phenylbenzyl)piperazine
• Piperazine
• D-3-Bromocamphor-8-sulfonic acid ammonium salt