ChemicalBook > Product Catalog > Organic Chemistry > Alcohols,Phenols,Phenol alcohols > Phenol derivatives > Delta3,2-Hydroxylbakuchiol
Delta3,2-Hydroxylbakuchiol
Delta3,2-Hydroxylbakuchiol Basic information
- Product Name:
- Delta3,2-Hydroxylbakuchiol
- Synonyms:
-
- Delta3,2-Hydroxylbakuchiol
- 13-Hydroxyisobakuchiol
- 4-[(1E,3S,5E)-3-Ethenyl-7-hydroxy-3,7-dimethyl-1,5-octadienyl]phenol
- Phenol, 4-[(1E,3S,5E)-3-ethenyl-7-hydroxy-3,7-dimethyl-1,5-octadienyl]-
- Delta3,2-Hydroxylbakuchiol/13-Hydroxyisobakuchiol
- Delta3,hydroxylbakuchiol
- CAS:
- 178765-49-6
- MF:
- C18H24O2
- MW:
- 272.38
- Mol File:
- 178765-49-6.mol
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Delta3,2-Hydroxylbakuchiol Usage And Synthesis
Uses
Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) isolated from Psoralea corylifolia (L.), is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50=0.58 μM) and norepinephrine transporter (NET) (IC50=0.69 μM) than for the serotonin transporter (SERT) (IC50=312.02 μM). 13-Hydroxyisobakuchiol has the potential for the research of disorders such as Parkinson's disease and depression[1].
References
[1] Gang Zhao, et al. Bakuchiol analogs inhibit monoamine transporters and regulate monoaminergic functions. Biochem Pharmacol. 2008 May 1;75(9):1835-47. DOI:10.1016/j.bcp.2008.01.014
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