Tigloylgomisin H Chemical Properties

Boiling point:

656.3±55.0 °C(Predicted)

Density 

1.144±0.06 g/cm3(Predicted)

pka

14.56±0.40(Predicted)

Tigloylgomisin H Usage And Synthesis

Uses

Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent[1].

References

[1] Lee SB, et al. Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2. Planta Med. 2009 Oct;75(12):1314-8. DOI:10.1055/s-0029-1185685
[2] Lee SB, et al. Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2. Planta Med. 2009 Oct;75(12):1314-8.

Tigloylgomisin H(66069-55-4)Related Product Information

• Gomisin L2
• (6S,7S,12aR)-5,6,7,8-Tetrahydro-2,3,10,11,12-pentamethoxy-6,7-dimethyldibenzo[a,c]cyclooctene-1,7-diol
• GOMISING
• gomisin D
• Benzoylgomisin H
• Angeloylgomisin O
• Isogomisin O
• Angeloylgomisin H
• gomisin J
• Gomisin S
• (-)Gomisin L1
• Angeloyl-(+)-gomisin K3
• (5R)-6β,7β-Dimethyl-1,2,3,12-tetramethoxy-10,11-methylenedioxy(5,6,7,8-tetrahydrodibenzo[a,c]cyclooctene)-5β,6α-diol 5-[(E)-2-methyl-2-butenoate]
• Angeloylgomisin P
• Angeloyl O iso gomisin
• Gomisin B
• Gomisin T
• Methylisogomisin O