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Axitinib Impurity a
Axitinib Impurity a Basic information
- Product Name:
- Axitinib Impurity a
- Synonyms:
-
- Axitinib Impurity a
- Axitinib Sulfoxide
- N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]benzamide
- N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfinyl]benzamide
- Axitinib Impurity 5/Axitinib Sulfoxide/N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide
- Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-
- Axitinib C
- Axitinib sulfoxide (AG028458
- CAS:
- 1347304-18-0
- MF:
- C22H18N4O2S
- MW:
- 402.47
- Mol File:
- 1347304-18-0.mol
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Axitinib Impurity a Chemical Properties
- Melting point:
- >225 (dec.)
- Boiling point:
- 720.6±60.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 11.70±0.40(Predicted)
- color
- Light Yellow
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Axitinib Impurity a Usage And Synthesis
Description
Axitinib sulfoxide is a major inactive metabolite of the tyrosine kinase inhibitor axitinib . It is formed from axitinib primarily by the cytochrome P450 (CYP) isoform CYP3A4 with minor contributions from CYP3A5 and CYP2C19.
Uses
Axitinib Sulfoxide is a major metabolite of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.
Axitinib Impurity aSupplier
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Axitinib Impurity a(1347304-18-0)Related Product Information
- Axitinib
- Axitinib Impurity b
- BenzaMide, 2-[(3-iodo-1H-indazol-6-yl)thio]-N-Methyl-
- 3,6-DIIODO (1H)INDAZOLE
- Axitinib Impurity 3
- Axitinib-13C-d3
- Axitinib Impurity d
- Axitinib Impurity 23
- Axitinib Impurity 26
- Axitinib Impurity 10
- Axitinib Impurity 4
- Axitinib Impurity 20
- Axitinib Impurity 18
- Axitinib Impurity 13
- 2-(1H-indazol-6-ylthio)-N-Methyl- BenzaMide
- Axitinib Impurity 3
- Axitinib Impurity 14
- Axitinib Impurity 19