Axitinib Impurity a Chemical Properties

Melting point:

>225 (dec.)

Boiling point:

720.6±60.0 °C(Predicted)

Density 

1.43±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

form 

Solid

pka

11.70±0.40(Predicted)

color 

Light Yellow

Axitinib Impurity a Usage And Synthesis

Description

Axitinib sulfoxide is a major inactive metabolite of the tyrosine kinase inhibitor axitinib . It is formed from axitinib primarily by the cytochrome P450 (CYP) isoform CYP3A4 with minor contributions from CYP3A5 and CYP2C19.

Uses

Axitinib Sulfoxide is a major metabolite of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

References

[1] MICHAEL A ZIENTEK. In Vitro Kinetic Characterization of Axitinib Metabolism.[J]. Drug Metabolism and Disposition, 2016, 44 1: 102-114. DOI: 10.1124/dmd.115.065615
[2] BILL J SMITH. Pharmacokinetics, metabolism, and excretion of [14C]axitinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in humans.[J]. ACS Applied Energy Materials, 2014: 918-931. DOI: 10.1124/dmd.113.056531

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