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Axitinib Impurity a

Basic information Safety Supplier Related

Axitinib Impurity a Basic information

Product Name:
Axitinib Impurity a
Synonyms:
  • Axitinib Impurity a
  • Axitinib Sulfoxide
  • N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]benzamide
  • N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfinyl]benzamide
  • Axitinib Impurity 5/Axitinib Sulfoxide/N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide
  • Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-
  • Axitinib C
  • Axitinib sulfoxide (AG028458
CAS:
1347304-18-0
MF:
C22H18N4O2S
MW:
402.47
Mol File:
1347304-18-0.mol
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Axitinib Impurity a Chemical Properties

Melting point:
>225 (dec.)
Boiling point:
720.6±60.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
11.70±0.40(Predicted)
color 
Light Yellow
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Axitinib Impurity a Usage And Synthesis

Description

Axitinib sulfoxide is a major inactive metabolite of the tyrosine kinase inhibitor axitinib . It is formed from axitinib primarily by the cytochrome P450 (CYP) isoform CYP3A4 with minor contributions from CYP3A5 and CYP2C19.

Uses

Axitinib Sulfoxide is a major metabolite of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

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