GSK5959 Chemical Properties

Boiling point:

527.3±50.0 °C(Predicted)

Density 

1.263±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 13 mg/mL (32.96 mM; Need ultrasonic and warming)

form 

Powder

pka

13.06±0.20(Predicted)

GSK5959 Usage And Synthesis

Description

GSK 5959 exhibits >100-fold selectivity for BRPF1 (IC50 = 80 nM) over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3, which is involved in the epigenetic regulation of gene expression and have been implicated in human cancer.

Uses

GSK5959 is as elective BRPF1 bromodomain inhibitor.

storage

Store at +4°C

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