Basic information Safety Supplier Related

GSK5959

Basic information Safety Supplier Related

GSK5959 Basic information

Product Name:
GSK5959
Synonyms:
  • GSK5959
  • BRPF1-IN-3
  • N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide
  • GSK-5959;GSK5959
  • CS-1636
  • Benzamide, N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxy-
  • BRPF3,GSK5959,bromodomain,Inhibitor,inhibit,BRD1,BRPF1,Epigenetic Reader Domain,GSK-5959,GSK 5959,BRPF2,epigenetics
  • N-(1,3-dimethyl-2-oxo-6-(piperidin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methoxybenzamide
CAS:
901245-65-6
MF:
C22H26N4O3
MW:
394.47
Product Categories:
  • Inhibitors
Mol File:
901245-65-6.mol
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GSK5959 Chemical Properties

Boiling point:
527.3±50.0 °C(Predicted)
Density 
1.263±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 13 mg/mL (32.96 mM; Need ultrasonic and warming)
form 
Powder
pka
13.06±0.20(Predicted)
color 
Light yellow to yellow
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GSK5959 Usage And Synthesis

Description

GSK 5959 exhibits >100-fold selectivity for BRPF1 (IC50 = 80 nM) over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3, which is involved in the epigenetic regulation of gene expression and have been implicated in human cancer.

Uses

GSK5959 is as elective BRPF1 bromodomain inhibitor.

storage

Store at +4°C

GSK5959Supplier

Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Email
sales@BioChemBest.com
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Email
info@chemexpress.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
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GSK5959(901245-65-6)Related Product Information