1,4-bis(trifluoromethyl)-2,5-dibromobenzene Chemical Properties

Melting point:

72.0-72.5 °C

Boiling point:

112.0 °C(Press: 40 Torr)

Density 

1.969±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

solid

color 

Faint yellow

InChI

InChI=1S/C8H2Br2F6/c9-5-1-3(7(11,12)13)6(10)2-4(5)8(14,15)16/h1-2H

InChIKey

ZEVVDSRCWJRHSX-UHFFFAOYSA-N

SMILES

C1(Br)=CC(C(F)(F)F)=C(Br)C=C1C(F)(F)F

Safety Information

HS Code 

2903998090

1,4-bis(trifluoromethyl)-2,5-dibromobenzene Usage And Synthesis

Synthesis

General procedure for the synthesis of 1,4-dibromo-2,5-bis(trifluoromethyl)benzene from 2,3-difluorotoluene: 1. 1,4-bis(trifluoromethyl)benzene (19 g, 88.7 mmol, ABCR), trifluoroacetic acid (250 ml, SDS), and 99% sulfuric acid (60 ml, Acros) were sequentially added to a 1-liter round-bottomed flask fitted with a condenser and magnetic stirrer. 2. The reaction mixture was heated to 60 °C at which temperature N-bromosuccinimide (47.4 g, 267 mmol, Aldrich) was added in batches and the dosing process lasted for 5 hours. 3. After completion of the addition, the reaction was kept at 60 °C with continued stirring for 48 hours. 4. The reaction mixture was poured into ice (500 ml) and precipitate was precipitated and collected by filtration. 5. The precipitate was dried under vacuum (1 mmHg) for 24 hours. 6. The dried product was purified by sublimation to give 30 g (91% yield) of white solid product 2,5-dibromo-1,4-bis(trifluoromethyl)benzene. Product characterization: - Melting point: 65±0.2°C; - 1H NMR (200MHz, CDCl3): δ 8.01 (2H, s); - 19F NMR (188MHz, CDCl3): δ -64.1 (2×CF3, s).

References

[1] Chemical Communications, 2005, # 3, p. 372 - 374
[2] Journal of the American Chemical Society, 2009, vol. 131, # 49, p. 17724 - 17725
[3] Journal of the American Chemical Society, 2010, vol. 132, # 3, p. 1127 - 1136
[4] Patent: US2010/209354, 2010, A1. Location in patent: Page/Page column 19
[5] Chemistry - A European Journal, 2010, vol. 16, # 36, p. 11028 - 11036