VALNEMULIN HYDROCHLORIDE Chemical Properties

Melting point:

140-143?C

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

Merck 

14,9911

InChIKey

MFBPRQKHDIVLOJ-AFFLPQGKSA-N

Safety Information

WGK Germany 

3

HS Code 

2941.90.5000

VALNEMULIN HYDROCHLORIDE Usage And Synthesis

Chemical Properties

White to Off-White Solid

Uses

Hydrochloride salt Valnemulin, semisynthetic antibiotic; derivative of pleuromutilin. Antibacterial.

Uses

Valnemulin hydrochloride is the salt prepared from valnemulin taking advantage of the basic amino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Valnemulin is a broad spectrum antibiotic used to control gastrointestinal infections in animals, and shows no cross resistance to other antibiotic classes. Like all the pleuromutilins, valnemulin inhibits protein synthesis by binding to domain V of 23S RNA.

Uses

Valnemulin Hydrochloride is a semisynthetic antibiotic; derivative of pleuromutilin. Antibacterial.

Biological Activity

Valnemulin Hydrochloride inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome. More specifically, it binds to the peptidyl transferase center of the ribosome and interferes with the transfer of amino acids to growing polypeptide chains, leading to the inhibition of protein synthesis and bacterial death.

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