Bis-Mal-Lysine-PEG4-TFP ester CAS#: 1426164-53-5

Bis-Mal-Lysine-PEG4-TFP ester Basic information

Product Name:

Bis-Mal-Lysine-PEG4-TFP ester

Synonyms:

Bis-Mal-Lysine-PEG4-TFP ester
4,7,10,13-Tetraoxa-16,23-diazahexacosanoic acid, 26-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-18-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]-17,24-dioxo-, 2,3,5,6-tetrafluorophenyl ester, (18S)-
Bis-MAL-Lysine-dPEG??-TFP ester (QBD-10631)
2,3,5,6-Tetrafluorophenyl (S)-26-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-18-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)-17,24-dioxo-4,7,10,13-tetraoxa-16,23-diazahexacosanoate

CAS:

1426164-53-5

MF:

C37H45F4N5O13

MW:

843.77

Mol File:

1426164-53-5.mol

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Bis-Mal-Lysine-PEG4-TFP ester Chemical Properties

Boiling point:: 1012.1±65.0 °C(Predicted)
Density: 1.364±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, protect from light
form: Solid
pka: 14.12±0.46(Predicted)
color: White to off-white

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Bis-Mal-Lysine-PEG4-TFP ester Usage And Synthesis

Description

Bis-Mal-Lysine-PEG4-TFP ester contains two malimide end groups which can react with thiol groups from pH 6.5 to 7.5 to form thiolester bonds. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG linker increases the compound's water solubility in aqueous environments.

Uses

Bis-Mal-Lysine-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Bis-Mal-Lysine-PEG4-TFP esterSupplier

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