Bromoacetamido-PEG3-Acid
Bromoacetamido-PEG3-Acid Basic information
- Product Name:
- Bromoacetamido-PEG3-Acid
- Synonyms:
-
- Bromoacetamido-PEG3-Acid
- Bromoacetamido-PEG3-CH2CH2COOH
- BrCH2CONH-PEG3-acid
- Bromoacetamido-PEG3-C2-acid
- Propanoic acid, 3-[2-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]ethoxy]-
- 1-bromo-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oic acid
- Bromoacetamido-PEG3-CH2CH2COOH/Propanoic acid, 3-[2-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]ethoxy]-
- CAS:
- 1807534-79-7
- MF:
- C11H20BrNO6
- MW:
- 342.18
- Mol File:
- 1807534-79-7.mol
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Bromoacetamido-PEG3-Acid Usage And Synthesis
Description
Bromoacetamido-PEG3-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Uses
Bromoacetamido-PEG3-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Bromoacetamido-PEG3-AcidSupplier
Jinan elephant international trading co., LTD
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Amatek Scientific Co. Ltd.
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Xi'an Confluore Biological Technology Co., Ltd.
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Jiangsu aikang biomedical research and development co., LTD
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TargetMol Chemicals Inc.
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