Hydroxy-PEG1-CH2CO2tBu Chemical Properties

Boiling point:

257.0±15.0 °C(Predicted)

Density 

1.048±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

liquid

pka

14.26±0.10(Predicted)

color 

Colourless

InChI

InChI=1S/C8H16O4/c1-8(2,3)12-7(10)6-11-5-4-9/h9H,4-6H2,1-3H3

InChIKey

GIDDJWYPWOFCCS-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)COCCO

Safety Information

HS Code 

2942000090

Hydroxy-PEG1-CH2CO2tBu Usage And Synthesis

Description

Hydroxy-PEG1-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Hydroxy-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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