Mal-PEG2-NHS ester CAS#: 1433997-01-3

Mal-PEG2-NHS ester Basic information

Product Name:

Mal-PEG2-NHS ester

Synonyms:

Mal-PEG2-NHS ester
2,5-dioxopyrrolidin-1-yl 3-(2-(2-(2,5-dioxo-2H-pyrrol-1(5H)-yl)ethoxy)ethoxy)propanoate
Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
Mal-PEG2-Osu
2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethoxy)propanoate
Mal-PEG2-CH2CH2COONHS
Maleimide-PEG2-NHS Ester 、MAL-PEG2-NHS

CAS:

1433997-01-3

MF:

C15H18N2O8

MW:

354.31

Product Categories:

ADCs Linkers
peg

Mol File:

1433997-01-3.mol

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Mal-PEG2-NHS ester Chemical Properties

Boiling point:: 524.3±60.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
solubility: Soluble in DCM
pka: -2.34±0.20(Predicted)
form: Oil
color: Colourless

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Mal-PEG2-NHS ester Usage And Synthesis

Description

Mal-PEG2-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Uses

Mal-?PEG2-?NHS Ester is a reagent used in the preparation of antibody-drug conjugates that bind to human-antigen targets in the effort to combat cancers.

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