Mal-PEG6-PFP Chemical Properties

Boiling point:

623.0±55.0 °C(Predicted)

Density 

1.353±0.06 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

pka

-2.34±0.20(Predicted)

form 

Liquid

color 

Off-white to light yellow

Mal-PEG6-PFP Usage And Synthesis

Description

Mal-PEG6-PFP is a PEG linker with maleimide and PFP moieties. Maleimides are thiol reactive between pH 6.5 and 7.5, forming thiolester bonds. The PFP is amine reactive and forms stable amide bonds. PFP was also found to be less susceptible toward hydrolysis than other amine reactive groups. The hydrophilic PEG linker increases the water solubility of a compound in aqueous environments. Increasing the number of units in the PEG chain ehnahces their solubility properties.

Uses

Mal-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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