Tos-PEG5-CH2CO2t-butyl ester
Tos-PEG5-CH2CO2t-butyl ester Basic information
- Product Name:
- Tos-PEG5-CH2CO2t-butyl ester
- Synonyms:
-
- Tos-PEG5-CH2CO2t-butyl ester
- Tos-PEG4-CH2COOtBu
- Tos-PEG5-CH2CO2tBu
- Tos-PEG4-CH2-Boc
- 3,6,9,12-Tetraoxatetradecanoic acid, 14-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester
- tert-butyl 2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]acetate
- 2-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid tert-butyl ester
- Tos-PEG4-t-butyl acetate
- CAS:
- 169751-73-9
- MF:
- C21H34O9S
- MW:
- 462.55
- Mol File:
- 169751-73-9.mol
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Tos-PEG5-CH2CO2t-butyl ester Chemical Properties
- Boiling point:
- 550.0±50.0 °C(Predicted)
- Density
- 1.163±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- form
- Liquid
- color
- Colorless to light yellow
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Tos-PEG5-CH2CO2t-butyl ester Usage And Synthesis
Description
Tos-PEG5-CH2CO2tBu is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
Uses
Tos-PEG4-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6
Tos-PEG5-CH2CO2t-butyl esterSupplier
Bide Pharmatech Ltd.
- Tel
- 400-164-7117 13681763483
- product02@bidepharm.com
Borenpharm Co., Ltd
- Tel
- 027-65563561
- sales@borenpharm.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
Jinan elephant international trading co., LTD
- Tel
- 13006575422@163.com
Shanghai Yihe Biological Technology Co., Ltd.
- Tel
- 021-68882955 17721395025
- 2423903095@qq.com
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Tos-PEG5-CH2CO2t-butyl ester(169751-73-9)Related Product Information
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- Tos-PEG21-Tos
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- TETRAETHYLENE GLYCOL DI-P-TOSYLATE
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- TOS-PEG5-THP
- Tos-PEG5 t-butyl ester
- Tos-PEG10-CH2CH2COOtBu
- Tos-PEG3-t-butyl ester
- Tos-PEG13-Tos
- (2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-acetic acid tert-butyl ester