GW806742X
GW806742X Basic information
- Product Name:
- GW806742X
- Synonyms:
-
- GW806742X
- CS-2659
- GW806742X;GW-806742X;GW 806742X
- 1-[4-[methyl-[2-(3-sulfamoylanilino)pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethoxy)phenyl]urea
- GW806742X ≥95%
- Benzenesulfonamide, 3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]-
- GW806742X >=98% (HPLC)
- 3-((4-(Methyl(4-(3-(4-(trifluoromethoxy)phenyl)ureido)phenyl)amino)pyrimidin-2-yl)amino)benzenesulfonamide
- CAS:
- 579515-63-2
- MF:
- C25H22F3N7O4S
- MW:
- 573.55
- Mol File:
- 579515-63-2.mol
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GW806742X Chemical Properties
- Density
- 1.524±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:100.0(Max Conc. mg/mL);174.35(Max Conc. mM)
- pka
- 10.09±0.60(Predicted)
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GW806742X Usage And Synthesis
Biological Activity
GW806742X, an ATP mimetic, is a potent MLKL inhibitor that binds the MLKL pseudokinase domain with a Kd of 9.3μM. It has anti-VEGFR2 activity (IC50=2 nM). It delays MLKL membrane translocation and inhibits necrosis.
in vitro
GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD -OPh) in a dose-dependent manner. GW806742X shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM.
target
| MLKL 9.3 μM (Kd) | VEGFR2 2 nM (IC 50 < /sub> ) |
GW806742XSupplier
Wuhan TCASChem Technology Co., Ltd.
- Tel
- 027-86697669 13986148687
- sales@tcaschem.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Pharmacodia (Beijing) Co.,Ltd
- Tel
- +86-400-851-9921
- sales@pharmacodia.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com