2-Methyl-3-nitroanisole Chemical Properties

Melting point:

54-56 °C (lit.)

Boiling point:

94-96°C 0,5mm

Density 

1.180±0.06 g/cm3(Predicted)

Flash point:

>230 °F

storage temp. 

Store at room temperature

solubility 

soluble in Methanol

form 

Powder or Crystalline Powder

color 

Yellow to pale brown

BRN 

2328599

InChI

InChI=1S/C8H9NO3/c1-6-7(9(10)11)4-3-5-8(6)12-2/h3-5H,1-2H3

InChIKey

HQCZLEAGIOIIMC-UHFFFAOYSA-N

SMILES

C1(OC)=CC=CC([N+]([O-])=O)=C1C

CAS DataBase Reference

4837-88-1(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1-methoxy-2-methyl-3-nitro-(4837-88-1)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

22-36/37-36-26

RIDADR 

2811

WGK Germany 

3

Hazard Note 

Harmful

PackingGroup 

III

HS Code 

29093090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

MSDS

• Language:English Provider:1-Methoxy-2-methyl-3-nitrobenzene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Methyl-3-nitroanisole Usage And Synthesis

Uses

2-Methyl-3-nitroanisole may be used in chemical synthesis studies.

Synthesis

A solution of dimethyl sulfoxide (80 mL) was added to a 500 mL three-necked vial at 25 ??. 29.7 g (0.32 mol) of methanol and 14 g (0.35 mol) of 60% sodium hydride were added slowly with stirring, the temperature was raised to 120 ??, and a solution of dimethyl sulfoxide containing 56.3 g (0.3 mol) of 2-methyl-3-nitrochlorobenzene was added dropwise. After dropwise reaction for 3 h. Decrease to 25 ??, add toluene (150 mL) and water (200 mL), partitioning, the aqueous layer was extracted with toluene (100 mL) twice, 50 mL each time, combined with the organic phase and washed with 5% aqueous sodium hydroxide (40 mL) once, partitioning. The organic layer was washed with water, the organic layer was dried with anhydrous sodium sulfate, filtered and evaporated. Get 2-methyl-3-nitro anisole.

Purification Methods

2-Methyl-5-nitroanisole crystallises from MeOH (yellow needles) and sublimes in vacuo. [Kuffner Monatsh Chem 91 1152 1960, Beilstein 6 I 178.]

2-Methyl-3-nitroanisole(4837-88-1)Related Product Information

• 4-Methylanisole
• Methyl acetate
• METHYL THIOPHENE-2-CARBOXYLATE
• Sodium 3-nitrobenzenesulphonate
• 4-Nitrobenzoic acid
• 2-Methyl-3-nitrophenol
• 3,5-Dimethylanisole
• 4-Bromo-3-nitroanisole
• Methyl acrylate
• 4-Chloro-3-nitroanisole
• Kresoxim-methyl
• Methylparaben
• Bensulfuron methyl
• Thiophanate-methyl
• Methyl
• 4-METHYL-3-NITROANISOLE 99%,4-METHYL-3-NITROANISOLE PESTANAL, 250 MG,4-METHYL-3-NITROANISOLE
• 1,3-Dinitrobenzene
• nitrotoluene