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ChemicalBook >  Product Catalog >  Biochemical Engineering >  Amino Acids and Derivatives >  Proline derivatives >  1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

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1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Basic information

Product Name:
1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
Synonyms:
  • N-BOC-(4S,2R)-4-FLUORO-2-PYRROLIDINECARBOXYLIC ACID
  • N-BOC-TRANS-4-FLUORO-L-PROLINE
  • N-T-BOC-TRANS-4-FLUORO-L-PROLINE
  • N-(TERT-BUTOXYCARBONYL)-(2S,4R)-4-FLUOROPROLINE
  • BOC-TRANS-4-FLUORO-L-PROLINE
  • (2S,4R)-N-Boc-trans-4-Fluoro-L-Proline
  • (2S,4R)-4-Fluoropyrrolidine-2-carboxylic acid, N4-BOC protected
  • trans-4-Fluoro-L-proline, N-BOC protected
CAS:
203866-14-2
MF:
C10H16FNO4
MW:
233.24
Product Categories:
  • Carboxylic Acids (Chiral)
  • Chiral Building Blocks
  • Synthetic Organic Chemistry
  • Chiral Building Blocks
  • Heterocyclic Building Blocks
  • Pyrrolidines
Mol File:
203866-14-2.mol
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1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Chemical Properties

Melting point:
115-119°C
Boiling point:
346.0±42.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
refractive index 
-69 ° (C=1, MeOH)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
3.53±0.40(Predicted)
color 
White to Almost white
optical activity
[α]22/D -65.0±5°, c = 1 in chloroform
InChIKey
YGWZXQOYEBWUTH-RQJHMYQMSA-N
CAS DataBase Reference
203866-14-2(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
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1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Usage And Synthesis

Chemical Properties

White powder

Uses

N-Boc-trans-4-fluoro-L-proline is a useful synthetic intermediate. It is used to prepare potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors. It is also used to synthesize pyrrolotriazines derivatives as pan-Aurora kinase inhibitors and anti-tumor agents.

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