Propargyl-PEG6-acid Chemical Properties

Boiling point:

462.8±45.0 °C(Predicted)

Density 

1.126±0.06 g/cm3(Predicted)

refractive index 

n/D 1.469

storage temp. 

-20°C

solubility 

Soluble in Water

form 

liquid

pka

4.28±0.10(Predicted)

color 

Colorless to light yellow

Propargyl-PEG6-acid Usage And Synthesis

Description

Propargyl-PEG6-acid comprises propargyl and carboxylic acid functional groups. The acid group reacts with primary amines in the presence of activators (e.g. EDC, or HATU).The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The molecule has good solubility in aqueous environment.

Uses

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

Propargyl-PEG6-acid(1951438-84-8)Related Product Information

• Propargyl-PEG2-acid
• propargyl-PEG3-Acid
• Propargyl-PEG4-thiol
• Propargyl-PEG10-acid
• Propargyl-PEG2-methylamine
• Propargyl-PEG17-t-butyl ester
• Propargyl-PEG14-t-butyl ester
• Propargyl-PEG8-acid
• Propargyl-PEG16-alcohol
• Propargyl-PEG7-t-butyl ester
• Propargyl-PEG17-acid
• Propargyl-PEG7-acid
• Propargyl-PEG15-t-butyl ester
• Propargyl-PEG9-t-butyl ester
• Propargyl-PEG7-alcohol
• Propargyl-PEG15-acid
• Propargyl-PEG8-t-butyl ester
• Propargyl-PEG6-Tos