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Val-Cit-PAB-MMAE

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Val-Cit-PAB-MMAE Basic information

Product Name:
Val-Cit-PAB-MMAE
Synonyms:
  • Val-Cit-PAB-MMAE
  • 4H-1-Benzopyran-4-one,7-hydroxy-4-(trifluoromethyl)-
  • Drug-Linker Conjugates for ADC,inhibit,Inhibitor,Val Cit PAB MMAE,ValCitPABMMAE
  • 4-((S)-2-((S)-2-Amino-3-methylbutanamido)-5-ureidopentanamido)benzyl ((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate
  • VCPMMAE
  • Val-Cit-PAB-MMAE, 10 mM in DMSO
  • N-Methyl-N-[[[4-[[L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
CAS:
644981-35-1
MF:
C58H94N10O12
MW:
1123.42676
Product Categories:
  • ADCs
  • ADC LINKER
Mol File:
644981-35-1.mol
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Val-Cit-PAB-MMAE Chemical Properties

storage temp. 
-20°C
solubility 
Soluble in DCM
form 
Solid
color 
White to off-white
InChIKey
WZEAGSMYTVSXQA-DQTLHWFHNA-N
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Val-Cit-PAB-MMAE Usage And Synthesis

Description

Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains a a protease-sensitive Val-Cit dipeptide, and a MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells.

Uses

Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

IC 50

Auristatin

References

[1] Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897. DOI:10.1158/1078-0432.CCR-09-2069

Val-Cit-PAB-MMAESupplier

SuZhou JianHua Pharmaceutical Co. Ltd Gold
Tel
13666392288
Email
jhyylcj@163.com
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Email
info@chemlin.com.cn
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
EnliPharma Technology Co., Ltd
Tel
0551-66399836 18955197623
Email
sales@enlipharma.com
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Email
marketing@targetmol.com
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