Val-Cit-PAB-MMAE
Val-Cit-PAB-MMAE Basic information
- Product Name:
- Val-Cit-PAB-MMAE
- Synonyms:
-
- Val-Cit-PAB-MMAE
- 4H-1-Benzopyran-4-one,7-hydroxy-4-(trifluoromethyl)-
- Drug-Linker Conjugates for ADC,inhibit,Inhibitor,Val Cit PAB MMAE,ValCitPABMMAE
- 4-((S)-2-((S)-2-Amino-3-methylbutanamido)-5-ureidopentanamido)benzyl ((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate
- VCPMMAE
- Val-Cit-PAB-MMAE, 10 mM in DMSO
- N-Methyl-N-[[[4-[[L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
- CAS:
- 644981-35-1
- MF:
- C58H94N10O12
- MW:
- 1123.42676
- Product Categories:
-
- ADCs
- ADC LINKER
- Mol File:
- 644981-35-1.mol
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Val-Cit-PAB-MMAE Chemical Properties
- storage temp.
- -20°C
- solubility
- Soluble in DCM
- form
- Solid
- color
- White to off-white
- InChIKey
- WZEAGSMYTVSXQA-DQTLHWFHNA-N
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Val-Cit-PAB-MMAE Usage And Synthesis
Description
Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains a a protease-sensitive Val-Cit dipeptide, and a MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells.
Uses
Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.
IC 50
Auristatin
References
[1] Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897. DOI:10.1158/1078-0432.CCR-09-2069
Val-Cit-PAB-MMAESupplier
SuZhou JianHua Pharmaceutical Co. Ltd Gold
- Tel
- 13666392288
- jhyylcj@163.com
Nanjing Chemlin Chemical Co., Ltd
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- 025-83697070
- info@chemlin.com.cn
Shanghai Topbiochem Technology Co., Ltd
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- 021-58170097
- info@topbiochem.com
EnliPharma Technology Co., Ltd
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- 0551-66399836 18955197623
- sales@enlipharma.com
TargetMol Chemicals Inc.
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- 021-021-33632979 15002134094
- marketing@targetmol.com